Entry Detail

General Information

Database ID: LDA0007240
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:MIR99AHG
Full Name:mir-99a-let-7c cluster host gene
Category:LncRNA
Species:Homo sapiens
Synonyms:C21orf34|C21orf35|DILA1|LINC00478|MONC
Chromosome:21
Strand:+
Coordinate:
Start Site(bp):16070488End Site(bp):16631727
External Links:
Ensembl ID:ENSG00000215386
Ensembl Transcript ID:N/A
Entrez Gene:388815.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:16   
More Information
Causal Disease Number:12
Network:
Top Causal Diseases:
Mycobacterium tuberculosis  (Score: 0.731059)
Pulmonary Fibrosis  (Score: 0.731059)
Endometrial Neoplasms  (Score: 0.731059)
Adenocarcinoma of Lung  (Score: 0.731059)
Stomach Neoplasms  (Score: 0.731059)
Pancreatic Neoplasms  (Score: 0.731059)
Mycobacterium tuberculosis  (Score: 0.731059)
Pulmonary Fibrosis  (Score: 0.731059)
Endometrial Neoplasms  (Score: 0.731059)
Adenocarcinoma of Lung  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:1380D016889
Disease Name:endometrial cancerEndometrial Neoplasms
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A uterine cancer that is located_in tissues lining the uterus.Tumors or cancer of ENDOMETRIUM, the mucous lining of the UTERUS. These neoplasms can be benign or malignant. Their classification and grading are based on the various cell types and the percent of undifferentiated cells.
Alias:endometrial Ca//endometrial neoplasm//malignant endometrial neoplasm//malignant neoplasm of endometrium//neoplasm of endometrium//primary malignant neoplasm of endometrium//tumor of EndometriumEndometrial Neoplasms//Endometrial Neoplasm//Neoplasm, Endometrial//Neoplasms, Endometrial//Endometrial Carcinoma//Carcinoma, Endometrial//Carcinomas, Endometrial//Endometrial Carcinomas//Endometrial Cancer//Cancer, Endometrial//Cancers, Endometrial//Endometrial Cancers//Endometrium Cancer//Cancer, Endometrium//Cancers, Endometrium//Cancer of the Endometrium//Carcinoma of Endometrium//Endometrium Carcinoma//Endometrium Carcinomas//Cancer of Endometrium//Endometrium Cancers

 

Disease Association Statistics

Total Associated ncRNA Number:232   
More Information
Causal ncRNA Number:178
Network:
Top Causal ncRNAs:
DLEU1  (Score: 0.999893)
hsa_circ_0000437  (Score: 0.999893)
hsa_circ_0000437  (Score: 0.999893)
DLEU1  (Score: 0.999893)
hsa_circ_0001776  (Score: 0.985791)
PCAT1  (Score: 0.985791)
hsa_circ_0001776  (Score: 0.985791)
PCAT1  (Score: 0.985791)
hsa_circ_0001610  (Score: 0.985791)
hsa_circ_0075960  (Score: 0.985791)
More Information

 

Evidence Support

Strong Evidence:In Vivo Experiment//Western Blot//Transfection//Flow Cytometry//qRT-PCR//FISH//Luciferase Report Assay//Cell Apoptosis Assay//Cell Cycle Assay//Invasion Assay//Transwell Assay
Weak Evidence:

 

Reference

[1] PubMed ID:34193130
Disease Name:Endometrial Neoplasms
Sample:endometrial carcinoma (EC) and patients
Dysfunction Pattern:Interaction(MiR-636/GLCE axis)
Validated Method:In Vivo Experiment//Western Blot//Transfection//Flow Cytometry//qRT-PCR//FISH//Luciferase Report Assay//Cell Apoptosis Assay//Cell Cycle Assay//Invasion Assay//Transwell Assay
Description:In this study, we found MONC is low expression in endometrial carcinoma (EC) and patients in the MONC high-expression group had a better prognosis. MONC and miR-636 are relatively co-localized in the cytoplasm. MONC directly inhibits the malignant biological behavior of ECSCs and ECCs by directly inhibiting miR-636. Simultaneously, miR-636 may indirectly reduce the expression of MONC. Down-regulation of miR-636 may promote GLCE expression by targeting the 3'-untranslated region (UTR) of the downstream gene GLCE, thereby inhibiting the progression of ECSCs.
Causality:Yes
Causal Description:MONC and miR-636 are relatively co-localized in the cytoplasm. MONC directly inhibits the malignant biological behavior of ECSCs and ECCs by directly inhibiting miR-636. Simultaneously, miR-636 may indirectly reduce the expression of MONC. Down-regulation of miR-636 may promote GLCE expression by targeting the 3'-untranslated region (UTR) of the downstream gene GLCE, thereby inhibiting the progression of ECSCs. In addition, we verified the tumor suppressive effect of MONC in nude mice, miR-636 can rescue the tumor suppressive effect of overexpressing MONC.
Clinical-realted Application: