Entry Detail

General Information

Database ID: LDA0007241
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:MIR99AHG
Full Name:mir-99a-let-7c cluster host gene
Category:LncRNA
Species:Homo sapiens
Synonyms:C21orf34|C21orf35|DILA1|LINC00478|MONC
Chromosome:21
Strand:+
Coordinate:
Start Site(bp):16070488End Site(bp):16631727
External Links:
Ensembl ID:ENSG00000215386
Ensembl Transcript ID:N/A
Entrez Gene:388815.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:16   
More Information
Causal Disease Number:12
Network:
Top Causal Diseases:
Mycobacterium tuberculosis  (Score: 0.731059)
Pulmonary Fibrosis  (Score: 0.731059)
Endometrial Neoplasms  (Score: 0.731059)
Adenocarcinoma of Lung  (Score: 0.731059)
Stomach Neoplasms  (Score: 0.731059)
Pancreatic Neoplasms  (Score: 0.731059)
Mycobacterium tuberculosis  (Score: 0.731059)
Pulmonary Fibrosis  (Score: 0.731059)
Endometrial Neoplasms  (Score: 0.731059)
Adenocarcinoma of Lung  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:3910D000077192
Disease Name:lung adenocarcinomaAdenocarcinoma of Lung
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A lung non-small cell carcinoma that derives_from epithelial cells of glandular origin.A carcinoma originating in the lung and the most common lung cancer type in never-smokers. Malignant cells exhibit distinct features such as glandular epithelial, or tubular morphology. Mutations in KRAS, EGFR, BRAF, and ERBB2 genes are associated with this cancer.
Alias:bronchogenic lung adenocarcinoma//nonsmall cell adenocarcinomaAdenocarcinoma of Lung//Lung Adenocarcinomas//Lung Adenocarcinoma//Adenocarcinoma, Lung//Adenocarcinomas, Lung

 

Disease Association Statistics

Total Associated ncRNA Number:656   
More Information
Causal ncRNA Number:386
Network:
Top Causal ncRNAs:
LINC00665  (Score: 1)
LINC00511  (Score: 1)
FAM83A-AS1  (Score: 1)
LINC00665  (Score: 1)
LINC00511  (Score: 1)
FAM83A-AS1  (Score: 1)
CCAT1  (Score: 0.999893)
H19  (Score: 0.999893)
SNHG17  (Score: 0.999893)
LINC00467  (Score: 0.999893)
More Information

 

Evidence Support

Strong Evidence:In Vivo Experiment//Western Blot//Migration Assay//qRT-PCR//FISH//Cell Apoptosis Assay//IHC//Invasion Assay//IF
Weak Evidence:

 

Reference

[1] PubMed ID:33931593
Disease Name:Adenocarcinoma of Lung
Sample:LUAD tissues
Dysfunction Pattern:Interaction(ANXA2 )
Validated Method:In Vivo Experiment//Western Blot//Migration Assay//qRT-PCR//FISH//Cell Apoptosis Assay//IHC//Invasion Assay//IF
Description:All four of these transcripts were downregulated in LUAD tissues partly due to the copy number deletion of the MIR99AHG gene. Mechanistically, the interaction between MIR99AHG and ANXA2 could accelerate the ANXA2-induced ATG16L+ vesicle biogenesis, thus promoting phagophore assembly. Additionally, miR-99a targeted a well-known autophagy suppressor, mammalian target of rapamycin (mTOR), thereby synergistically promoting autophagy and postponing LUAD progression with MIR99AHG.
Causality:Yes
Causal Description:MIR99AHG suppressed proliferation and metastasis and promoted autophagy both in vitro and in vivo.
Clinical-realted Application:Both MIR99AHG and miR-99a expression was positively correlated with the survival of LUAD patients.