Entry Detail

General Information

Database ID: LDA0007253
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:MIR99AHG
Full Name:mir-99a-let-7c cluster host gene
Category:LncRNA
Species:Homo sapiens
Synonyms:C21orf34|C21orf35|DILA1|LINC00478|MONC
Chromosome:21
Strand:+
Coordinate:
Start Site(bp):16070488End Site(bp):16631727
External Links:
Ensembl ID:ENSG00000215386
Ensembl Transcript ID:N/A
Entrez Gene:388815.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:16   
More Information
Causal Disease Number:12
Network:
Top Causal Diseases:
Mycobacterium tuberculosis  (Score: 0.731059)
Pulmonary Fibrosis  (Score: 0.731059)
Endometrial Neoplasms  (Score: 0.731059)
Adenocarcinoma of Lung  (Score: 0.731059)
Stomach Neoplasms  (Score: 0.731059)
Pancreatic Neoplasms  (Score: 0.731059)
Mycobacterium tuberculosis  (Score: 0.731059)
Pulmonary Fibrosis  (Score: 0.731059)
Endometrial Neoplasms  (Score: 0.731059)
Adenocarcinoma of Lung  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:1793D010190
Disease Name:pancreatic cancerPancreatic Neoplasms
Category:Disease OntologyMeSH
Type:Neoplasms
Define:An endocrine gland cancer located_in the pancreas.Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).
Alias:Ca body of pancreas//Ca head of pancreas//Ca tail of pancreas//malignant neoplasm of body of pancreas//malignant neoplasm of head of pancreas//malignant neoplasm of tail of pancreas//pancreas neoplasm//pancreatic neoplasm//pancreatic tumorPancreatic Neoplasms//Neoplasm, Pancreatic//Pancreatic Neoplasm//Pancreas Neoplasms//Neoplasm, Pancreas//Neoplasms, Pancreas//Pancreas Neoplasm//Neoplasms, Pancreatic//Cancer of Pancreas//Pancreas Cancers//Pancreas Cancer//Cancer, Pancreas//Cancers, Pancreas//Pancreatic Cancer//Cancer, Pancreatic//Cancers, Pancreatic//Pancreatic Cancers//Cancer of the Pancreas

 

Disease Association Statistics

Total Associated ncRNA Number:322   
More Information
Causal ncRNA Number:280
Network:
Top Causal ncRNAs:
DANCR  (Score: 1)
XIST  (Score: 1)
LINC00261  (Score: 1)
DANCR  (Score: 1)
XIST  (Score: 1)
LINC00261  (Score: 1)
CASC2  (Score: 0.999893)
CASC2  (Score: 0.999893)
LINC00460  (Score: 0.999893)
LINC00460  (Score: 0.999893)
More Information

 

Evidence Support

Strong Evidence:In Vivo Experiment//RNA Pull-Down//Western Blot//Transwell Assay//Transfection//Wound Healing Assay//qRT-PCR//FISH//IF//RIP//Luciferase Report Assay//Colony Formation Assay//EdU Staining//ChIP
Weak Evidence:

 

Reference

[1] PubMed ID:34911544
Disease Name:Pancreatic Neoplasms
Sample:PCa cell lines
Dysfunction Pattern:Interaction(FOXA1/MIR99AHG/miR-3129-5p/ELAVL1/NOTCH2 axis)
Validated Method:In Vivo Experiment//RNA Pull-Down//ChIP//Western Blot//Transfection//Wound Healing Assay//qRT-PCR//FISH//IF//RIP//Luciferase Report Assay//Colony Formation Assay//EdU Staining//Transwell Assay
Description:MIR99AHG was distinctly overexpressed in PCa cell lines. Moreover, MIR99AHG up-regulation was induced by transcription factor forkhead box A1 (FOXA1). Furthermore, MIR99AHG modulated notch receptor 2 (NOTCH2) expression and stimulated Notch signaling pathway through sequestering microRNA-3129-5p (miR-3129-5p) and recruiting ELAV like RNA binding protein 1 (ELAVL1).
Causality:Yes
Causal Description:MIR99AHG deficiency abrogated PCa cell proliferation, migration and invasion.
Clinical-realted Application: