Entry Detail


General Information

Database ID: LDA0007260
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:MRPS30-DT
Full Name:MRPS30 divergent transcript
Category:LncRNA
Species:Homo sapiens
Synonyms:BRCAT54
Chromosome:5
Strand:-
Coordinate:
Start Site(bp):44744328End Site(bp):44808793
External Links:
Ensembl ID:ENSG00000251141
Ensembl Transcript ID:N/A
Entrez Gene:100506674.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:8   
More Information
Causal Disease Number:8
Network:
Top Causal Diseases:
Carcinoma, Non-Small-Cell Lung  (Score: 0.731059)
Neuroma, Acoustic  (Score: 0.731059)
Triple Negative Breast Neoplasms  (Score: 0.731059)
Breast Neoplasms  (Score: 0.731059)
Carcinoma, Non-Small-Cell Lung  (Score: 0.731059)
Neuroma, Acoustic  (Score: 0.731059)
Triple Negative Breast Neoplasms  (Score: 0.731059)
Breast Neoplasms  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:12689D009464
Disease Name:acoustic neuromaNeuroma, Acoustic
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A benign SCHWANNOMA of the eighth cranial nerve (VESTIBULOCOCHLEAR NERVE), mostly arising from the vestibular branch (VESTIBULAR NERVE) during the fifth or sixth decade of life. Clinical manifestations include HEARING LOSS; HEADACHE; VERTIGO; TINNITUS; and FACIAL PAIN. Bilateral acoustic neuromas are associated with NEUROFIBROMATOSIS 2. (From Adams et al., Principles of Neurology, 6th ed, p673)
Alias:Vestibular Neurilemmoma//Vestibular schwannomaNeuroma, Acoustic//Acoustic Neuroma//Acoustic Neuromas//Neuromas, Acoustic//Schwannoma, Acoustic//Acoustic Schwannoma//Acoustic Schwannomas//Schwannomas, Acoustic//Neurinoma of the Acoustic Nerve//Neurilemoma, Acoustic//Acoustic Neurilemoma//Acoustic Neurilemomas//Neurilemomas, Acoustic//Schwannoma, Vestibular//Schwannomas, Vestibular//Vestibular Schwannomas//Vestibular Schwannoma//Acoustic Tumor//Acoustic Tumors//Tumor, Acoustic//Tumors, Acoustic//Neurilemmoma, Acoustic//Acoustic Neurilemmoma//Acoustic Neurilemmomas//Neurilemmomas, Acoustic//Neurinoma, Acoustic//Acoustic Neurinoma//Acoustic Neurinomas//Neurinomas, Acoustic//Cerebellopontine Angle Acoustic Neuroma//Acoustic Neuroma, Cerebellopontine Angle//Neuroma, Acoustic, Unilateral//Melanocytic Vestibular Schwannoma//Melanocytic Vestibular Schwannomas//Schwannoma, Melanocytic Vestibular//Schwannomas, Melanocytic Vestibular//Vestibular Schwannoma, Melanocytic//Vestibular Schwannomas, Melanocytic//Angle Tumor//Angle Tumors//Tumor, Angle//Tumors, Angle//Cerebellopontine Angle Tumor//Angle Tumor, Cerebellopontine//Angle Tumors, Cerebellopontine//Cerebellopontine Angle Tumors//Tumor, Cerebellopontine Angle//Tumors, Cerebellopontine Angle

 

Disease Association Statistics

Total Associated ncRNA Number:2   
More Information
Causal ncRNA Number:2
Network:
Top Causal ncRNAs:
MRPS30-DT  (Score: 0.731059)
MRPS30-DT  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:RNA Pull-Down//Transfection//qRT-PCR//Luciferase Report Assay//BrdU
Weak Evidence:

 

Reference

[1] PubMed ID:35137654
Disease Name:Neuroma, Acoustic
Sample:VS samples
Dysfunction Pattern:Interaction(microRNA-21 )
Validated Method:RNA Pull-Down//Transfection//qRT-PCR//Luciferase Report Assay//BrdU
Description:We found that BRCAT54 was downregulated in VS samples than that in VN samples, while miR-21 was upregulated in VS samples.BRCAT54 and miR-21 were not closely correlated. BRCAT54 was detected in both nuclear and cytoplasm samples, and BRCAT54 directly interacted with miR-21. However, BRCAT54 and miR-21 did not affect the expression of each other.
Causality:Yes
Causal Description:BRCAT54 suppressed primary VS cell proliferation and inhibited the role of miR-21 in promoting cell proliferation.
Clinical-realted Application: