Entry Detail

General Information

Database ID: LDA0007275
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:MRPL23-AS1
Full Name:MRPL23 antisense RNA 1
Category:LncRNA
Species:Homo sapiens
Synonyms:TP53LC10
Chromosome:11
Strand:-
Coordinate:
Start Site(bp):1983209End Site(bp):1989920
External Links:
Ensembl ID:ENSG00000288320
Ensembl Transcript ID:N/A
Entrez Gene:100133545.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:4   
More Information
Causal Disease Number:4
Network:
Top Causal Diseases:
Carcinoma, Adenoid Cystic  (Score: 0.731059)
Osteosarcoma  (Score: 0.731059)
Carcinoma, Adenoid Cystic  (Score: 0.731059)
Osteosarcoma  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:D003528
Disease Name:Carcinoma, Adenoid Cystic
Category:MeSH
Type:Neoplasms
Define:Carcinoma characterized by bands or cylinders of hyalinized or mucinous stroma separating or surrounded by nests or cords of small epithelial cells. When the cylinders occur within masses of epithelial cells, they give the tissue a perforated, sievelike, or cribriform appearance. Such tumors occur in the mammary glands, the mucous glands of the upper and lower respiratory tract, and the salivary glands. They are malignant but slow-growing, and tend to spread locally via the nerves. (Dorland, 27th ed)
Alias:Carcinoma, Adenoid Cystic//Adenoid Cystic Carcinoma//Adenoid Cystic Carcinomas//Carcinomas, Adenoid Cystic//Cystic Carcinoma, Adenoid//Cystic Carcinomas, Adenoid//Adenocystic Carcinoma//Adenocystic Carcinomas//Carcinoma, Adenocystic//Carcinomas, Adenocystic//Cylindroma//Cylindromas

 

Disease Association Statistics

Total Associated ncRNA Number:14   
More Information
Causal ncRNA Number:8
Network:
Top Causal ncRNAs:
ADAMTS9-AS2  (Score: 0.731059)
MRPL23-AS1  (Score: 0.731059)
hsa_circ_001982  (Score: 0.731059)
hsa_circ_0011946  (Score: 0.731059)
ADAMTS9-AS2  (Score: 0.731059)
MRPL23-AS1  (Score: 0.731059)
hsa_circ_001982  (Score: 0.731059)
hsa_circ_0011946  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:Western Blot//Flow Cytometry//qRT-PCR//IHC//ChIP
Weak Evidence:

 

Reference

[1] PubMed ID:35175670
Disease Name:Carcinoma, Adenoid Cystic
Sample:patient tissues and cell lines
Dysfunction Pattern:Interaction(MRPL23-AS1/p19INK4D axis )
Validated Method:Western Blot//Flow Cytometry//qRT-PCR//IHC//ChIP
Description:MRPL23-AS1 recruited the EZH2 to the promoter region of p19INK4D, inhibited p19INK4D expression, and promoted tumor cell anoikis resistance. The novel MRPL23-AS1/p19INK4D axis may be a potential SACC biomarker or therapeutic target.
Causality:Yes
Causal Description:The functional experiments showed that MPRL23-AS1 could promote anoikis resistance in vitro.
Clinical-realted Application: