Entry Detail


General Information

Database ID: LDA0007285
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:MNX1-AS1
Full Name:MNX1 antisense RNA 1 (head to head)
Category:LncRNA
Species:Homo sapiens
Synonyms:CCAT5|MAYA
Chromosome:7
Strand:+
Coordinate:
Start Site(bp):157010857End Site(bp):157016424
External Links:
Ensembl ID:ENSG00000243479
Ensembl Transcript ID:N/A
Entrez Gene:645249.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:36   
More Information
Causal Disease Number:36
Network:
Top Causal Diseases:
Stomach Neoplasms  (Score: 0.999893)
Lung Neoplasms  (Score: 0.999893)
Lung Neoplasms  (Score: 0.999893)
Stomach Neoplasms  (Score: 0.999893)
Adenocarcinoma of Lung  (Score: 0.985791)
Squamous Cell Carcinoma of Head and Neck  (Score: 0.985791)
Adenocarcinoma of Lung  (Score: 0.985791)
Squamous Cell Carcinoma of Head and Neck  (Score: 0.985791)
Carcinoma, Hepatocellular  (Score: 0.731059)
Breast Neoplasms  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:0050861
Disease Name:colorectal adenocarcinoma
Category:Disease Ontology
Type:Neoplasms
Define:A colorectal carcinoma that derives_from epithelial cells of glandular origin.
Alias:

 

Disease Association Statistics

Total Associated ncRNA Number:16   
More Information
Causal ncRNA Number:10
Network:
Top Causal ncRNAs:
AK077216  (Score: 0.731059)
AWPPH  (Score: 0.731059)
PCED1B-AS1  (Score: 0.731059)
MNX1-AS1  (Score: 0.731059)
MEG3  (Score: 0.731059)
AK077216  (Score: 0.731059)
AWPPH  (Score: 0.731059)
PCED1B-AS1  (Score: 0.731059)
MNX1-AS1  (Score: 0.731059)
MEG3  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:qRT-PCR
Weak Evidence:

 

Reference

[1] PubMed ID:36226248
Disease Name:colorectal adenocarcinoma
Sample:COAD patients and cells
Dysfunction Pattern:Interaction(LncRNA MNX1-AS1/PPFIA4/AKT/HIF-1α )
Validated Method:qRT-PCR
Description:COAD patients with high expression of the lncRNA MNX1-AS1 have poor prognosis. LncRNA MNX1-AS1/PPFIA4 activates the downstream AKT/HIF-1α signaling pathway to promote COAD development. LY29004 significantly inhibits the tumorigenic ability of lncRNA MNX1-AS1 and PPFIA4.
Causality:Yes
Causal Description: LncRNA MNX1-AS1 promotes the stemness of COAD cells. PPFIA4 mediates lncRNA MNX1-AS1 expression and affects COAD cell stemness. LncRNA MNX1-AS1 accelerates proliferation and migration, while it suppresses apoptosis. LncRNA MNX1-AS1/PPFIA4 accelerates tumor growth in COAD model.
Clinical-realted Application:COAD patients with high expression of the lncRNA MNX1-AS1 have poor prognosis.