Entry Detail

General Information

Database ID: LDA0007292
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:MSC-AS1
Full Name:MSC antisense RNA 1
Category:LncRNA
Species:Homo sapiens
Synonyms:MAT1
Chromosome:8
Strand:+
Coordinate:
Start Site(bp):71843123End Site(bp):72056312
External Links:
Ensembl ID:ENSG00000235531
Ensembl Transcript ID:N/A
Entrez Gene:100132891.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:22   
More Information
Causal Disease Number:16
Network:
Top Causal Diseases:
Nasopharyngeal carcinoma  (Score: 0.985791)
Carcinoma, Hepatocellular  (Score: 0.985791)
Melanoma  (Score: 0.985791)
Nasopharyngeal carcinoma  (Score: 0.985791)
Carcinoma, Hepatocellular  (Score: 0.985791)
Melanoma  (Score: 0.985791)
Stomach Neoplasms  (Score: 0.959542)
Stomach Neoplasms  (Score: 0.959542)
Glioma  (Score: 0.731059)
Colorectal Neoplasms  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:4467
Disease Name:clear cell renal cell carcinoma
Category:Disease Ontology
Type:Neoplasms
Define:A renal cell carcinoma that has_material_basis_in cells that appear very pale or clear when examined under microscope.
Alias:Clear cell carcinoma of kidney//clear cell kidney carcinoma//conventional (Clear cell) renal cell carcinoma//conventional renal cell carcinoma//renal clear cell carcinoma

 

Disease Association Statistics

Total Associated ncRNA Number:6   
More Information
Causal ncRNA Number:4
Network:
Top Causal ncRNAs:
CDKN2B-AS1  (Score: 0.731059)
MSC-AS1  (Score: 0.731059)
CDKN2B-AS1  (Score: 0.731059)
MSC-AS1  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:qRT-PCR
Weak Evidence:

 

Reference

[1] PubMed ID:31916281
Disease Name:clear cell renal cell carcinoma
Sample:
Dysfunction Pattern:regulation[miR-3924/WNT5A/β-catenin axis]
Validated Method:qRT-PCR
Description:In this study, MSC-AS1 was dramatically upregulated in KIRC and correlated with dismal prognosis of KIRC patients.This study revealed that MSC-AS1 regulates KIRC cell proliferation and migration via miR-3924/WNT5A/β-catenin axis.
Causality:Yes
Causal Description:Knockdown of MSC-AS1 would suppress the proliferative and migratory properties of KIRC cells.
Clinical-realted Application: