Entry Detail

General Information

Database ID: LDA0007296
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:NEF
Full Name:S100 calcium binding protein B
Category:LncRNA
Species:Homo sapiens
Synonyms:NEF|S100|S100-B|S100beta
Chromosome:21
Strand:-
Coordinate:
Start Site(bp):46598604End Site(bp):46605082
External Links:
Ensembl ID:N/A
Ensembl Transcript ID:N/A
Entrez Gene:6285.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:20   
More Information
Causal Disease Number:18
Network:
Top Causal Diseases:
Thyroid Cancer, Papillary  (Score: 0.731059)
Small Cell Lung Carcinoma  (Score: 0.731059)
Cholangiocarcinoma  (Score: 0.731059)
cervical squamous cell carcinoma  (Score: 0.731059)
stomach carcinoma  (Score: 0.731059)
Squamous Cell Carcinoma of Head and Neck  (Score: 0.731059)
Triple Negative Breast Neoplasms  (Score: 0.731059)
Glioma  (Score: 0.731059)
Esophageal Squamous Cell Carcinoma  (Score: 0.731059)
Thyroid Cancer, Papillary  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:3744
Disease Name:cervical squamous cell carcinoma
Category:Disease Ontology
Type:Neoplasms
Define:A cervix carcinoma that has_material_basis_in squamous cells of the cervix.
Alias:squamous cell carcinoma of cervix//squamous cell carcinoma of the Cervix Uteri

 

Disease Association Statistics

Total Associated ncRNA Number:52   
More Information
Causal ncRNA Number:50
Network:
Top Causal ncRNAs:
MCM3AP-AS1  (Score: 0.985791)
MCM3AP-AS1  (Score: 0.985791)
MAGI2-AS3  (Score: 0.985791)
MAGI2-AS3  (Score: 0.985791)
SLC16A1-AS1  (Score: 0.731059)
GATA6-AS  (Score: 0.731059)
BLACAT1  (Score: 0.731059)
CASC9-1  (Score: 0.731059)
DGUOK-AS1  (Score: 0.731059)
MACC1-AS1  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:qRT-PCR//Transwell Assay//Western Blot
Weak Evidence:

 

Reference

[1] PubMed ID:30910843
Disease Name:cervical squamous cell carcinoma
Sample:blood
Dysfunction Pattern:Interaction[TGF-β pathway]
Validated Method:qRT-PCR//Western Blot//Transwell Assay
Description:We found that expression of NEF in cervical tissues (tumor tissues for CSCC patients) and serum was significantly down-regulated in HPV-negative CSCC patients than in healthy controls and HPV positive patients, but no significant differences were found between healthy controls and HPV positive patients.Therefore, we conclude that lncRNA NEF may inhibit the migration and invasion of HPV-negative cervical squamous cell carcinoma by inhibiting TGF-β pathway.
Causality:Yes
Causal Description:NEF overexpression inhibited the migration and invasion of HPV-negative but not HPV-positive CSCC cells.
Clinical-realted Application:Low serum levels of NEF distinguished HPV-negative CSCC patients from healthy controls and indicated poor survival.