Entry Detail

General Information

Database ID: LDA0007298
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:NEF
Full Name:S100 calcium binding protein B
Category:LncRNA
Species:Homo sapiens
Synonyms:NEF|S100|S100-B|S100beta
Chromosome:21
Strand:-
Coordinate:
Start Site(bp):46598604End Site(bp):46605082
External Links:
Ensembl ID:N/A
Ensembl Transcript ID:N/A
Entrez Gene:6285.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:20   
More Information
Causal Disease Number:18
Network:
Top Causal Diseases:
Thyroid Cancer, Papillary  (Score: 0.731059)
Small Cell Lung Carcinoma  (Score: 0.731059)
Cholangiocarcinoma  (Score: 0.731059)
cervical squamous cell carcinoma  (Score: 0.731059)
stomach carcinoma  (Score: 0.731059)
Squamous Cell Carcinoma of Head and Neck  (Score: 0.731059)
Triple Negative Breast Neoplasms  (Score: 0.731059)
Glioma  (Score: 0.731059)
Esophageal Squamous Cell Carcinoma  (Score: 0.731059)
Thyroid Cancer, Papillary  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:D055752
Disease Name:Small Cell Lung Carcinoma
Category:MeSH
Type:Neoplasms
Define:A form of highly malignant lung cancer that is composed of small ovoid cells (SMALL CELL CARCINOMA).
Alias:Small Cell Lung Carcinoma//Small Cell Lung Cancer//Oat Cell Lung Cancer//Small Cell Cancer Of The Lung//Carcinoma, Small Cell Lung//Oat Cell Carcinoma of Lung

 

Disease Association Statistics

Total Associated ncRNA Number:28   
More Information
Causal ncRNA Number:24
Network:
Top Causal ncRNAs:
circPVT1  (Score: 0.731059)
KCNQ1OT1  (Score: 0.731059)
LUADT1  (Score: 0.731059)
LINC01555  (Score: 0.731059)
LINC01116  (Score: 0.731059)
CASC11  (Score: 0.731059)
ZFPM2-AS1  (Score: 0.731059)
MCM3AP-AS1  (Score: 0.731059)
NEF  (Score: 0.731059)
HIF1A-AS2  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:qRT-PCR//Transwell Assay//Western Blot
Weak Evidence:

 

Reference

[1] PubMed ID:31186707
Disease Name:Small Cell Lung Carcinoma
Sample:SCLC tissues
Dysfunction Pattern:Interaction[TGF-β1]
Validated Method:qRT-PCR//Western Blot//Transwell Assay
Description:The results demonstrated that the expression level of lncRNA-NEF was lower in patients with SCLC compared with that in healthy controls. lncRNA-NEF overexpression inhibited SCLC cell migration and invasion, resulting in TGF-β1 downregulation, while treatment with exogenous TGF-β1 reduced the inhibitory effects of lncRNA-NEF overexpression on migration and invasion.
Causality:Yes
Causal Description:lncRNA-NEF overexpression inhibited SCLC cell migration and invasion, resulting in TGF-β1 downregulation, while treatment with exogenous TGF-β1 reduced the inhibitory effects of lncRNA-NEF overexpression on migration and invasion.
Clinical-realted Application: