Entry Detail

General Information

Database ID: LDA0007309
Species: Homo sapiens
Confidence Score: 0.985791
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:MSC-AS1
Full Name:MSC antisense RNA 1
Category:LncRNA
Species:Homo sapiens
Synonyms:MAT1
Chromosome:8
Strand:+
Coordinate:
Start Site(bp):71843123End Site(bp):72056312
External Links:
Ensembl ID:ENSG00000235531
Ensembl Transcript ID:N/A
Entrez Gene:100132891.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:22   
More Information
Causal Disease Number:16
Network:
Top Causal Diseases:
Nasopharyngeal carcinoma  (Score: 0.985791)
Carcinoma, Hepatocellular  (Score: 0.985791)
Melanoma  (Score: 0.985791)
Nasopharyngeal carcinoma  (Score: 0.985791)
Carcinoma, Hepatocellular  (Score: 0.985791)
Melanoma  (Score: 0.985791)
Stomach Neoplasms  (Score: 0.959542)
Stomach Neoplasms  (Score: 0.959542)
Glioma  (Score: 0.731059)
Colorectal Neoplasms  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:1909D008545
Disease Name:melanomaMelanoma
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A cell type cancer that has_material_basis_in abnormally proliferating cells derives_from melanocytes which are found in skin, the bowel and the eye.A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)
Alias:Naevocarcinoma//malignant melanomaMelanoma//Melanomas//Malignant Melanoma//Malignant Melanomas//Melanoma, Malignant//Melanomas, Malignant

 

Disease Association Statistics

Total Associated ncRNA Number:164   
More Information
Causal ncRNA Number:154
Network:
Top Causal ncRNAs:
hsa_circ_0079593  (Score: 0.999893)
NEAT1  (Score: 0.999893)
hsa_circ_0079593  (Score: 0.999893)
NEAT1  (Score: 0.999893)
MEG3  (Score: 0.985791)
MALAT1  (Score: 0.985791)
TUG1  (Score: 0.985791)
TUG1  (Score: 0.985791)
TINCR  (Score: 0.985791)
LINC-PINT  (Score: 0.985791)
More Information

 

Evidence Support

Strong Evidence:In Vivo Experiment//RNA Pull-Down//IHC//Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay//ELISA//Colony Formation Assay//EdU Staining//Transwell Assay
Weak Evidence:

 

Reference

[1] PubMed ID:34218464
Disease Name:Melanoma
Sample:melanoma cell lines
Dysfunction Pattern:Interaction(miR-302a-3p/IGF2BP2/LEF1 axis)
Validated Method:In Vivo Experiment//RNA Pull-Down//Western Blot//qRT-PCR//RIP//Luciferase Report Assay//Colony Formation Assay//EdU Staining//Transwell Assay
Description:It was observed that MSC-AS1 and lymphoid enhancer-binding factor 1 (LEF1) were remarkably up-regulated while microRNA-302a-3p (miR-302a-3p) down-regulated in melanoma cell lines.Furthermore, MSC-AS1 regulated LEF1 expression through sponging miR-302a-3p and recruiting insulin like growth factor 2 mRNA-binding protein 2 (IGF2BP2). Eventually, LEF1 overexpression rescued cell progression impaired by MSC-AS1 knock-down.
Causality:Yes
Causal Description:. The silencing of MSC-AS1 hindered cell proliferation, migration and epithelial-mesenchymal transition (EMT) in vitro and tumor growth in vivo.
Clinical-realted Application:

[2] PubMed ID:36206100
Disease Name:Melanoma
Sample:melanoma tissues and cells
Dysfunction Pattern:Interaction(miR-330-3p/ YAP1 axis)
Validated Method:In Vivo Experiment//RNA Pull-Down//IHC//Western Blot//CCK8//Luciferase Report Assay//ELISA//Colony Formation Assay
Description:Results showed that lncRNA MSC-AS1 was upregulated in melanoma tissues and cells. High expression of MAS-AS1 was positively correlated with a poor prognosis. Pull-down and luciferase reporter demonstrated that miR-330-3p specifically binds directly to YAP1 and MSC-AS1, respectively. MSC-AS1 promoted the expression of YAP1 by downregulating miR-330-3p.
Causality:No
Causal Description:
Clinical-realted Application:Results showed that lncRNA MSC-AS1 was upregulated in melanoma tissues and cells. High expression of MAS-AS1 was positively correlated with a poor prognosis.