Entry Detail

General Information

Database ID: LDA0007317
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:NNT-AS1
Full Name:NNT antisense RNA 1
Category:LncRNA
Species:Homo sapiens
Synonyms:-
Chromosome:5
Strand:-
Coordinate:
Start Site(bp):43573185End Site(bp):43603230
External Links:
Ensembl ID:ENSG00000248092
Ensembl Transcript ID:N/A
Entrez Gene:100652772.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:26   
More Information
Causal Disease Number:20
Network:
Top Causal Diseases:
Cholangiocarcinoma  (Score: 0.999893)
Stomach Neoplasms  (Score: 0.999893)
Stomach Neoplasms  (Score: 0.999893)
Cholangiocarcinoma  (Score: 0.999893)
Prostatic Neoplasms  (Score: 0.985791)
Lung Neoplasms  (Score: 0.985791)
Lung Neoplasms  (Score: 0.985791)
Prostatic Neoplasms  (Score: 0.985791)
Endometrial Neoplasms  (Score: 0.731059)
Carcinoma, Renal Cell  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:1380D016889
Disease Name:endometrial cancerEndometrial Neoplasms
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A uterine cancer that is located_in tissues lining the uterus.Tumors or cancer of ENDOMETRIUM, the mucous lining of the UTERUS. These neoplasms can be benign or malignant. Their classification and grading are based on the various cell types and the percent of undifferentiated cells.
Alias:endometrial Ca//endometrial neoplasm//malignant endometrial neoplasm//malignant neoplasm of endometrium//neoplasm of endometrium//primary malignant neoplasm of endometrium//tumor of EndometriumEndometrial Neoplasms//Endometrial Neoplasm//Neoplasm, Endometrial//Neoplasms, Endometrial//Endometrial Carcinoma//Carcinoma, Endometrial//Carcinomas, Endometrial//Endometrial Carcinomas//Endometrial Cancer//Cancer, Endometrial//Cancers, Endometrial//Endometrial Cancers//Endometrium Cancer//Cancer, Endometrium//Cancers, Endometrium//Cancer of the Endometrium//Carcinoma of Endometrium//Endometrium Carcinoma//Endometrium Carcinomas//Cancer of Endometrium//Endometrium Cancers

 

Disease Association Statistics

Total Associated ncRNA Number:232   
More Information
Causal ncRNA Number:178
Network:
Top Causal ncRNAs:
DLEU1  (Score: 0.999893)
hsa_circ_0000437  (Score: 0.999893)
hsa_circ_0000437  (Score: 0.999893)
DLEU1  (Score: 0.999893)
hsa_circ_0001776  (Score: 0.985791)
PCAT1  (Score: 0.985791)
hsa_circ_0001776  (Score: 0.985791)
PCAT1  (Score: 0.985791)
hsa_circ_0001610  (Score: 0.985791)
hsa_circ_0075960  (Score: 0.985791)
More Information

 

Evidence Support

Strong Evidence:qRT-PCR//RNA Pull-Down//RIP
Weak Evidence:

 

Reference

[1] PubMed ID:34976175
Disease Name:Endometrial Neoplasms
Sample:EC tissues and cell lines
Dysfunction Pattern:Interaction( miR-30c/NPM1)
Validated Method:qRT-PCR//RNA Pull-Down//RIP
Description:NNT-AS1 and NPM1 expressions in EC tissues and cell lines were higher than in benign endometrium and normal endometrial epithelial cells (EECs). miR-30c expression in EC tissues and cell lines was lower than in benign endometrium and normal EECs. NNT-AS1 interacted with miR-30c, and miR-30c negatively regulated NPM1 expression. Overexpression of NNT-AS1 increased NPM1 expression in EC cells, while overexpression of miR-30c reversed the effect.
Causality:Yes
Causal Description:Estradiol (E2) promoted the proliferation of EC cells, small interfering RNA (siRNA) against NNT-AS1 inhibited EC cell proliferation, miR-30c inhibitor promoted cell proliferation, and NPM1 siRNA inhibited cell proliferation. E2 increased tumor volume, and NNT-AS1 interference reduced tumor volume in vivo.
Clinical-realted Application: