Entry Detail

General Information

Database ID: LDA0007322
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:NEAT1
Full Name:nuclear paraspeckle assembly transcript 1
Category:LncRNA
Species:Homo sapiens
Synonyms:LINC00084|NCRNA00084|TP53LC15|TncRNA|VINC
Chromosome:11
Strand:+
Coordinate:
Start Site(bp):65422798End Site(bp):65445540
External Links:
Ensembl ID:ENSG00000245532
Ensembl Transcript ID:N/A
Entrez Gene:283131.0
NONCODE ID:N/A
RefSeq Accession:NR_131012.1

 

ncRNA Association Statistics

Total Associated Disease Number:190   
More Information
Causal Disease Number:146
Network:
Top Causal Diseases:
Parkinson Disease  (Score: 1)
Ovarian Neoplasms  (Score: 1)
Non-alcoholic Fatty Liver Disease  (Score: 1)
Parkinson Disease  (Score: 1)
Leukemia, Myeloid, Acute  (Score: 1)
Osteosarcoma  (Score: 1)
Osteosarcoma  (Score: 1)
Leukemia, Myeloid, Acute  (Score: 1)
Colorectal Neoplasms  (Score: 1)
Carcinoma, Hepatocellular  (Score: 1)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:255D006391
Disease Name:hemangiomaHemangioma
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A cardiovascular organ benign neoplasm that has_material_basis_in endothelial cells that line blood vessels and is characterised by increased number of normal or abnormal vessels filled with blood.A vascular anomaly due to proliferation of BLOOD VESSELS that forms a tumor-like mass. The common types involve CAPILLARIES and VEINS. It can occur anywhere in the body but is most frequently noticed in the SKIN and SUBCUTANEOUS TISSUE. (from Stedman, 27th ed, 2000)
Alias:Hemangioma//Hemangiomas//Hemangioma, Intramuscular//Hemangiomas, Intramuscular//Intramuscular Hemangioma//Intramuscular Hemangiomas//Hemangioma, Histiocytoid//Hemangiomas, Histiocytoid//Histiocytoid Hemangioma//Histiocytoid Hemangiomas//Angioma//Chorioangioma//Chorioangiomas//Chorangioma//Chorangiomas

 

Disease Association Statistics

Total Associated ncRNA Number:12   
More Information
Causal ncRNA Number:12
Network:
Top Causal ncRNAs:
circAP2A2  (Score: 0.731059)
NEAT1  (Score: 0.731059)
MEG3  (Score: 0.731059)
MEG8  (Score: 0.731059)
OIP5-AS1  (Score: 0.731059)
MCM3AP-AS1  (Score: 0.731059)
circAP2A2  (Score: 0.731059)
NEAT1  (Score: 0.731059)
MEG3  (Score: 0.731059)
MEG8  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Transwell Assay
Weak Evidence:

 

Reference

[1] PubMed ID:30928097
Disease Name:Hemangioma
Sample:HA tissues
Dysfunction Pattern:Interaction[miR-361-5p/VEGFA pathway]
Validated Method:Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Transwell Assay
Description: We found that compared with normal skin tissues, NEAT1 expression was elevated, whereas miR-361-5p decreased in HA tissues especially in proliferating phase HAs.NEAT1 functioned as a competing endogenous RNA to regulate VEGFA expression via sponging miR-361-5p. Taken together, these findings indicate that NEAT1 promotes the proliferation and migration, whereas inhibits the apoptosis of HemECs via regulating miR-361-5p/VEGFA axis.
Causality:Yes
Causal Description: Downregulation of NEAT1 significantly suppressed the viability, PCNA expression and migration, but increased apoptotic cell numbers and caspase-3 activity of HemECs.
Clinical-realted Application: