Entry Detail

General Information

Database ID: LDA0007333
Species: Homo sapiens
Confidence Score: 0.999893
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:NNT-AS1
Full Name:NNT antisense RNA 1
Category:LncRNA
Species:Homo sapiens
Synonyms:-
Chromosome:5
Strand:-
Coordinate:
Start Site(bp):43573185End Site(bp):43603230
External Links:
Ensembl ID:ENSG00000248092
Ensembl Transcript ID:N/A
Entrez Gene:100652772.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:26   
More Information
Causal Disease Number:20
Network:
Top Causal Diseases:
Cholangiocarcinoma  (Score: 0.999893)
Stomach Neoplasms  (Score: 0.999893)
Stomach Neoplasms  (Score: 0.999893)
Cholangiocarcinoma  (Score: 0.999893)
Prostatic Neoplasms  (Score: 0.985791)
Lung Neoplasms  (Score: 0.985791)
Lung Neoplasms  (Score: 0.985791)
Prostatic Neoplasms  (Score: 0.985791)
Endometrial Neoplasms  (Score: 0.731059)
Carcinoma, Renal Cell  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:4928D018281
Disease Name:intrahepatic cholangiocarcinomaCholangiocarcinoma
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A cholangiocarcinoma that arises from the intrahepatic bile duct epithelium in any site of the intrahepatic biliary tree.A malignant tumor arising from the epithelium of the BILE DUCTS.
Alias:Intrahepatic bile duct carcinoma//peripheral CholangiocarcinomaCholangiocarcinoma//Cholangiocarcinomas//Cholangiocellular Carcinoma//Carcinoma, Cholangiocellular//Carcinomas, Cholangiocellular//Cholangiocellular Carcinomas//Extrahepatic Cholangiocarcinoma//Cholangiocarcinoma, Extrahepatic//Cholangiocarcinomas, Extrahepatic//Extrahepatic Cholangiocarcinomas//Intrahepatic Cholangiocarcinoma//Cholangiocarcinoma, Intrahepatic//Cholangiocarcinomas, Intrahepatic//Intrahepatic Cholangiocarcinomas

 

Disease Association Statistics

Total Associated ncRNA Number:164   
More Information
Causal ncRNA Number:144
Network:
Top Causal ncRNAs:
NNT-AS1  (Score: 0.999893)
NNT-AS1  (Score: 0.999893)
SNHG3  (Score: 0.985791)
MEG3  (Score: 0.985791)
NEAT1  (Score: 0.985791)
TTN-AS1  (Score: 0.985791)
SNHG1  (Score: 0.985791)
AGAP2-AS1  (Score: 0.985791)
CASC2  (Score: 0.985791)
PVT1  (Score: 0.985791)
More Information

 

Evidence Support

Strong Evidence:Western Blot//ISH//Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//BrdU//Transwell Assay
Weak Evidence:

 

Reference

[1] PubMed ID:31632521
Disease Name:Cholangiocarcinoma
Sample:CCA tissue
Dysfunction Pattern:Regulation[NNT-AS1/miR-142-5p/HMGA2 axis]
Validated Method:ISH//qRT-PCR//Luciferase Report Assay//Western Blot
Description:LncRNA NNT-AS1 was found highly expressed in CCA.Mechanistically, we demonstrated that NNT-AS1 might function as a ceRNA in regulating HMGA2 (high mobility group AT-hook 2) through competitively binding to miR-142-5p in CCA. Moreover, we showed that NNT-AS1 regulated epithelial-mesenchymal transition in CCA.
Causality:Yes
Causal Description:Functional studies showed that NNT-AS1 knockdown inhibited cell proliferation, migration and invasion of CCA cells in vitro. Conversely, NNT-AS1 overexpression showed the opposite biological effects. In a tumor xenograft model, we confirmed that NNT-AS1 knockdown could significantly inhibit the growth of CCA, while NNT-AS1 overexpression promoted CCA development.
Clinical-realted Application:Upregulated NNT-AS1 expression was tightly associated with clinical malignancies and predicted poor prognosis of CCA patients.

[2] PubMed ID:31616187
Disease Name:Cholangiocarcinoma
Sample:CCA tissue,cell lines
Dysfunction Pattern:Interaction[miR-485/BCL9]
Validated Method:Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Transwell Assay
Description: In this study, NNT-AS1 was expressed at high levels in CCA and closely associated with poor prognosis of patients with CCA.Moreover, NNT-AS1 directly bounded to miR-485 and further regulated BCL9. Finally, rescue assays verified that NNT-AS1 modulated the tumorigenesis of CCA by regulating miR-485.
Causality:Yes
Causal Description:NNT-AS1 knockdown impaired cell proliferation, suppressed CCA cell migration and invasion, and restrained tumor growth in vitro.
Clinical-realted Application: In this study, NNT-AS1 was expressed at high levels in CCA and closely associated with poor prognosis of patients with CCA

[3] PubMed ID:32019904
Disease Name:Cholangiocarcinoma
Sample:CCA tissues and cell lines
Dysfunction Pattern:regulation[down-regulating miR-203]
Validated Method:BrdU//qRT-PCR//Flow Cytometry//Western Blot
Description:NNT-AS1 overexpression was appeared in CCA tissues and cell lines.NNT-AS1 promoted proliferation, EMT and PI3K/AKT and ERK1/2 pathways in CCLP1 and TFK1 cells through down-regulating miR-203.
Causality:Yes
Causal Description:Proliferation was promoted by NNT-AS1 overexpression in CCLP1 and TFK1 cells.
Clinical-realted Application: