Entry Detail

General Information

Database ID: LDA0007341
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:MIR31HG
Full Name:MIR31 host gene
Category:LncRNA
Species:Homo sapiens
Synonyms:LncHIFCAR|hsa-lnc-31
Chromosome:9
Strand:-
Coordinate:
Start Site(bp):21454268End Site(bp):21559798
External Links:
Ensembl ID:ENSG00000171889
Ensembl Transcript ID:N/A
Entrez Gene:554202.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:24   
More Information
Causal Disease Number:22
Network:
Top Causal Diseases:
Adenocarcinoma of Lung  (Score: 0.985791)
Adenocarcinoma of Lung  (Score: 0.985791)
Colorectal Neoplasms  (Score: 0.985791)
Colorectal Neoplasms  (Score: 0.985791)
Nasopharyngeal carcinoma  (Score: 0.731059)
Glioblastoma  (Score: 0.731059)
Uterine Cervical Neoplasms  (Score: 0.731059)
Stomach Neoplasms  (Score: 0.731059)
Urinary Bladder Neoplasms  (Score: 0.731059)
Thyroid Neoplasms  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:3498
Disease Name:pancreatic ductal adenocarcinoma
Category:Disease Ontology
Type:Neoplasms
Define:A pancreatic adenocarcinoma that derives_from pancreatic duct cells.
Alias:ductal adenocarcinoma of the pancreas

 

Disease Association Statistics

Total Associated ncRNA Number:178   
More Information
Causal ncRNA Number:110
Network:
Top Causal ncRNAs:
NEAT1  (Score: 0.985791)
NEAT1  (Score: 0.985791)
circMYOF  (Score: 0.731059)
circBFAR  (Score: 0.731059)
hsa_circ_000684  (Score: 0.731059)
circSLIT2  (Score: 0.731059)
hsa_circ_0005105  (Score: 0.731059)
circEYA3  (Score: 0.731059)
circNEIL3  (Score: 0.731059)
hsa_circ_0047744  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:qRT-PCR//Western Blot
Weak Evidence:

 

Reference

[1] PubMed ID:35743003
Disease Name:pancreatic ductal adenocarcinoma
Sample:
Dysfunction Pattern:Expression(highly expressed)
Validated Method:qRT-PCR//Western Blot
Description: In this study, a cancer genomics analysis predicted that MIR31HG overexpression was positively correlated with poorer disease-free survival of pancreatic ductal adenocarcinoma (PDAC) patients, which was associated with upregulation of genes related to TGFβ signaling and the EMT.
Causality:Yes
Causal Description: In vitro evidence demonstrated that TGFβ induced MIR31HG expression in PDAC cells, and knockdown of MIR31HG expression reversed TGFβ-induced EMT phenotypes and cancer cell migration.
Clinical-realted Application: In this study, a cancer genomics analysis predicted that MIR31HG overexpression was positively correlated with poorer disease-free survival of pancreatic ductal adenocarcinoma (PDAC) patients, which was associated with upregulation of genes related to TGFβ signaling and the EMT.