Entry Detail

General Information

Database ID: LDA0007368
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:MIR22HG
Full Name:MIR22 host gene
Category:LncRNA
Species:Homo sapiens
Synonyms:C17orf91
Chromosome:17
Strand:-
Coordinate:
Start Site(bp):1711504End Site(bp):1716272
External Links:
Ensembl ID:ENSG00000282800
Ensembl Transcript ID:N/A
Entrez Gene:84981.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:18   
More Information
Causal Disease Number:18
Network:
Top Causal Diseases:
Stomach Neoplasms  (Score: 0.731059)
Esophageal Squamous Cell Carcinoma  (Score: 0.731059)
Adenocarcinoma Of Esophagus  (Score: 0.731059)
Colorectal Neoplasms  (Score: 0.731059)
Prostatic Neoplasms  (Score: 0.731059)
Cholangiocarcinoma  (Score: 0.731059)
Glioma  (Score: 0.731059)
Osteosarcoma  (Score: 0.731059)
Carcinoma, Hepatocellular  (Score: 0.731059)
Stomach Neoplasms  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:C562730
Disease Name:Adenocarcinoma Of Esophagus
Category:MeSH
Type:Neoplasms
Define:A malignant GLANDULAR NEOPLASM that originates mostly from BARRETT ESOPHAGUS. Esophageal adenocarcinomas are similar to esophageal SQUAMOUS CELL CARCINOMAS morphologically; tumor cells are usually papillary or tubular. Germline mutations in MSR1, CTHRC1, and ASCC1 have been identified. OMIM: 614266
Alias:

 

Disease Association Statistics

Total Associated ncRNA Number:4   
More Information
Causal ncRNA Number:4
Network:
Top Causal ncRNAs:
PVT1  (Score: 0.731059)
MIR22HG  (Score: 0.731059)
PVT1  (Score: 0.731059)
MIR22HG  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:Cell Proliferation Assay//qRT-PCR//Colony Formation Assay//Western Blot
Weak Evidence:

 

Reference

[1] PubMed ID:31291201
Disease Name:Adenocarcinoma Of Esophagus
Sample:cell lines
Dysfunction Pattern:Regulation[ STAT3/c-Myc/FAK signaling]
Validated Method:Cell Proliferation Assay//qRT-PCR//Colony Formation Assay//Western Blot
Description:Mechanistically, MIR22HG silencing decreased the expression of STAT3/c-Myc/p-FAK proteins and induced apoptosis in EAC cell lines.
Causality:Yes
Causal Description: In this study, abrogation of MIR22HG inhibited cell proliferation, colony formation, invasion and migration in EAC 3 cell lines (OE33, OE19 and FLO-1).
Clinical-realted Application: