Entry Detail

General Information

Database ID: LDA0007408
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:NKX2-1-AS1
Full Name:NKX2-1 antisense RNA 1
Category:LncRNA
Species:Homo sapiens
Synonyms:-
Chromosome:14
Strand:+
Coordinate:
Start Site(bp):36519278End Site(bp):36523016
External Links:
Ensembl ID:ENSG00000253563
Ensembl Transcript ID:N/A
Entrez Gene:100506237.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:2   
More Information
Causal Disease Number:2
Network:
Top Causal Diseases:
Stomach Neoplasms  (Score: 0.731059)
Stomach Neoplasms  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:10534D013274
Disease Name:stomach cancerStomach Neoplasms
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A gastrointestinal system cancer that is located_in the stomach.Tumors or cancer of the STOMACH.
Alias:gastric cancer//gastric neoplasmStomach Neoplasms//Neoplasm, Stomach//Stomach Neoplasm//Neoplasms, Stomach//Gastric Neoplasms//Gastric Neoplasm//Neoplasm, Gastric//Neoplasms, Gastric//Cancer of Stomach//Stomach Cancers//Gastric Cancer//Cancer, Gastric//Cancers, Gastric//Gastric Cancers//Stomach Cancer//Cancer, Stomach//Cancers, Stomach//Cancer of the Stomach//Gastric Cancer, Familial Diffuse

 

Disease Association Statistics

Total Associated ncRNA Number:1648   
More Information
Causal ncRNA Number:1044
Network:
Top Causal ncRNAs:
NORAD  (Score: 1)
SNHG1  (Score: 1)
UCA1  (Score: 1)
NEAT1  (Score: 1)
MALAT1  (Score: 1)
SNHG12  (Score: 1)
DLX6-AS1  (Score: 1)
UCA1  (Score: 1)
SNHG3  (Score: 1)
H19  (Score: 1)
More Information

 

Evidence Support

Strong Evidence:In Vivo Experiment//IHC//Western Blot//Tube Formation Assay//Migration Assay//CCK8//qRT-PCR//FISH//RIP//Luciferase Report Assay//Cell Cycle Assay//Colony Formation Assay//Invasion Assay
Weak Evidence:

 

Reference

[1] PubMed ID:33512745
Disease Name:Stomach Neoplasms
Sample:GC cell lines and tumor tissues
Dysfunction Pattern:Interaction(miR-145-5p/SERPINE1/VEGFR-2)
Validated Method:In Vivo Experiment//Western Blot//Tube Formation Assay//Migration Assay//CCK8//qRT-PCR//Colony Formation Assay//FISH//RIP//Luciferase Report Assay//Cell Cycle Assay//IHC//Invasion Assay
Description:The results indicated that NKX2-1-AS1 expression was upregulated in GC cell lines and tumor tissues. RIP and dual-luciferase assays revealed that the microRNA miR-145-5p is a direct target of NKX2-1-AS1 and that NKX2-1-AS1 serves as a ceRNA to sponge miRNA and regulate angiogenesis in GC. Moreover, serpin family E member 1 (SERPINE1) is an explicit target for miR-145-5p; besides, the NKX2-1-AS1/miR-145-5p axis induces the translation of SERPINE1, thus activating the VEGFR-2 signaling pathway to promote tumor progression and angiogenesis.
Causality:Yes
Causal Description:Overexpression of NKX2-1-AS1 was significantly associated with tumor progression and enhanced angiogenesis. Functionally, NKX2-1-AS1 overexpression promoted GC cell proliferation, metastasis, invasion, and angiogenesis, while NKX2-1-AS1 knockdown restored these effects, both in vitro and in vivo.
Clinical-realted Application: