Entry Detail

General Information

Database ID: LDA0007415
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:NNT-AS1
Full Name:NNT antisense RNA 1
Category:LncRNA
Species:Homo sapiens
Synonyms:-
Chromosome:5
Strand:-
Coordinate:
Start Site(bp):43573185End Site(bp):43603230
External Links:
Ensembl ID:ENSG00000248092
Ensembl Transcript ID:N/A
Entrez Gene:100652772.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:26   
More Information
Causal Disease Number:20
Network:
Top Causal Diseases:
Cholangiocarcinoma  (Score: 0.999893)
Stomach Neoplasms  (Score: 0.999893)
Stomach Neoplasms  (Score: 0.999893)
Cholangiocarcinoma  (Score: 0.999893)
Prostatic Neoplasms  (Score: 0.985791)
Lung Neoplasms  (Score: 0.985791)
Lung Neoplasms  (Score: 0.985791)
Prostatic Neoplasms  (Score: 0.985791)
Endometrial Neoplasms  (Score: 0.731059)
Carcinoma, Renal Cell  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:3907
Disease Name:lung squamous cell carcinoma
Category:Disease Ontology
Type:Neoplasms
Define:A non-small cell lung carcinoma that has_material_basis_in the squamous cell.
Alias:Epidermoid cell carcinoma of the lung

 

Disease Association Statistics

Total Associated ncRNA Number:92   
More Information
Causal ncRNA Number:48
Network:
Top Causal ncRNAs:
PITPNA-AS1  (Score: 0.985791)
PITPNA-AS1  (Score: 0.985791)
MIR205HG  (Score: 0.985791)
MIR205HG  (Score: 0.985791)
LINC00519  (Score: 0.731059)
circTP63  (Score: 0.731059)
BBOX1-AS1  (Score: 0.731059)
ATB  (Score: 0.731059)
LINC00668  (Score: 0.731059)
MAGI2-AS3  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:Western Blot//Flow Cytometry//qRT-PCR//RIP//Luciferase Report Assay//Transwell Assay
Weak Evidence:

 

Reference

[1] PubMed ID:32514270
Disease Name:lung squamous cell carcinoma
Sample:LUSC tissues and cell lines
Dysfunction Pattern:regulation[miR-22/FOXM1 axis]
Validated Method:Western Blot//Flow Cytometry//qRT-PCR//RIP//Luciferase Report Assay//Transwell Assay
Description: NNT-AS1 and FOXM1 were up-regulated but miR-22 was down-regulated in LUSC tissues and cell lines. LncRNA NNT-AS1 contributes to cell carcinogenesis in LUSC by regulating the miR-22/FOXM1 axis, providing a novel insight into the pathogenesis of LUSC and a new potential therapeutic target for LUSC treatment.
Causality:Yes
Causal Description:NNT-AS1 was a sponge of miR-22, and NNT-AS1 deletion suppressed the migration and invasion but induced apoptosis in LUSC cells.
Clinical-realted Application: