Entry Detail

General Information

Database ID: LDA0007437
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:NCK1-DT
Full Name:NCK1 divergent transcript
Category:LncRNA
Species:Homo sapiens
Synonyms:NCK1-AS1|SLC35G2-AS1
Chromosome:3
Strand:-
Coordinate:
Start Site(bp):136841976End Site(bp):136862063
External Links:
Ensembl ID:ENSG00000239213
Ensembl Transcript ID:N/A
Entrez Gene:101927597.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:26   
More Information
Causal Disease Number:24
Network:
Top Causal Diseases:
Carcinoma, Non-Small-Cell Lung  (Score: 0.999893)
Carcinoma, Non-Small-Cell Lung  (Score: 0.999893)
Squamous Cell Carcinoma of Head and Neck  (Score: 0.985791)
Uterine Cervical Neoplasms  (Score: 0.985791)
Stomach Neoplasms  (Score: 0.985791)
Esophageal Squamous Cell Carcinoma  (Score: 0.985791)
Esophageal Squamous Cell Carcinoma  (Score: 0.985791)
Squamous Cell Carcinoma of Head and Neck  (Score: 0.985791)
Stomach Neoplasms  (Score: 0.985791)
Uterine Cervical Neoplasms  (Score: 0.985791)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:1936D050197
Disease Name:atherosclerosisAtherosclerosis
Category:Disease OntologyMeSH
Type:Cardiovascular Diseases
Define:A thickening and loss of elasticity of the walls of ARTERIES that occurs with formation of ATHEROSCLEROTIC PLAQUES within the ARTERIAL INTIMA.
Alias:Atherosclerosis//Atheroscleroses//Atherogenesis//Atherogeneses

 

Disease Association Statistics

Total Associated ncRNA Number:206   
More Information
Causal ncRNA Number:96
Network:
Top Causal ncRNAs:
XIST  (Score: 0.999893)
H19  (Score: 0.999893)
XIST  (Score: 0.999893)
H19  (Score: 0.999893)
MIAT  (Score: 0.985791)
TUG1  (Score: 0.985791)
MIAT  (Score: 0.985791)
PVT1  (Score: 0.985791)
TUG1  (Score: 0.985791)
PVT1  (Score: 0.985791)
More Information

 

Evidence Support

Strong Evidence:Western Blot//Transfection//qRT-PCR//Luciferase Report Assay//Cell Proliferation Assay
Weak Evidence:

 

Reference

[1] PubMed ID:34986861
Disease Name:Atherosclerosis
Sample:AS blood samples and ox-LDL stimulated vascular smooth muscle cells
Dysfunction Pattern:Interaction( miR-1197/COX10 axis)
Validated Method:Western Blot//Transfection//qRT-PCR//Luciferase Report Assay//Cell Proliferation Assay
Description:NCK1-AS1 was significantly upregulated in AS blood samples and ox-LDL stimulated vascular smooth muscle cells (VSMCs). NCK1-AS1 could positively regulate COX10 expression by directly sponging miR-1197. Moreover, co-transfection of sh-NCK1-AS1 and miR-1197 inhibitor, or co-transfection of sh-NCK1-AS1 and pc-COX10 (COX10 overexpressing plasmid) obviously reduced cell viability, promoted cell apoptosis, and increased MDA level in VSMCs followed by ox-LDL treatment for 24 h compared to that in sh-NCK1-AS1 transfected VSMCs.
Causality:Yes
Causal Description:Knockdown of NCK1-AS1 increased cell viability, reduced cell apoptosis and MDA level, and also inhibited the expression of inflammatory cytokines (IL-1β, IL-6 and TNK-α) in ox-LDL stimulated VSMCs.
Clinical-realted Application: