Entry Detail

General Information

Database ID: LDA0007504
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:NCAPG2
Full Name:non-SMC condensin II complex subunit G2
Category:LncRNA
Species:Homo sapiens
Synonyms:3KS|CAP-G2|CAPG2|LUZP5|MTB|hCAP-G2
Chromosome:7
Strand:-
Coordinate:
Start Site(bp):158631169End Site(bp):158704804
External Links:
Ensembl ID:ENSG00000146918
Ensembl Transcript ID:N/A
Entrez Gene:54892.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:4   
More Information
Causal Disease Number:2
Network:
Top Causal Diseases:
Lung Neoplasms  (Score: 0.731059)
Lung Neoplasms  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:1324D008175
Disease Name:lung cancerLung Neoplasms
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A respiratory system cancer that is located_in the lung.Tumors or cancer of the LUNG.
Alias:Lung Neoplasms//Pulmonary Neoplasms//Neoplasms, Lung//Lung Neoplasm//Neoplasm, Lung//Neoplasms, Pulmonary//Neoplasm, Pulmonary//Pulmonary Neoplasm//Lung Cancer//Cancer, Lung//Cancers, Lung//Lung Cancers//Pulmonary Cancer//Cancer, Pulmonary//Cancers, Pulmonary//Pulmonary Cancers//Cancer of the Lung//Cancer of Lung

 

Disease Association Statistics

Total Associated ncRNA Number:344   
More Information
Causal ncRNA Number:282
Network:
Top Causal ncRNAs:
OIP5-AS1  (Score: 0.999893)
OIP5-AS1  (Score: 0.999893)
MNX1-AS1  (Score: 0.999893)
NEAT1  (Score: 0.999893)
MNX1-AS1  (Score: 0.999893)
NEAT1  (Score: 0.999893)
circHIPK3  (Score: 0.985791)
GAS5  (Score: 0.985791)
PCAT1  (Score: 0.985791)
NNT-AS1  (Score: 0.985791)
More Information

 

Evidence Support

Strong Evidence:CCK8//qRT-PCR//IHC//Migration Assay
Weak Evidence:

 

Reference

[1] PubMed ID:35664767
Disease Name:Lung Neoplasms
Sample:LUAD tissues and cells
Dysfunction Pattern:Interaction(LncRNA-AL035458.2/hsa-miR-181a-5p Axis)
Validated Method:CCK8//qRT-PCR//IHC//Migration Assay
Description: In this study, we investigated the role of NCAPG2 in LUAD and found that the expression of NCAPG2 in LUAD tissues was significantly higher than that of NCAPG2 expression in adjacent normal tissues. Finally, we found that AL139385.1 was upregulated in LUAD cancer tissues and cell lines. Knockdown of NCAPG2 inhibited cell proliferation, cell migration, and cell invasion of LUAD in vitro. More importantly, we established the AL035458.2/hsa-miR-181a-5p axis as the most likely upstream ncRNA-related pathway of NCAPG2 in LUAD.
Causality:Yes
Causal Description: Knockdown of NCAPG2 inhibited cell proliferation, cell migration, and cell invasion of LUAD in vitro.
Clinical-realted Application:Kaplan-Meier survival analysis showed that patients with higher NCAPG2 expression correlated with unfavorable clinical outcomes.