Entry Detail

General Information

Database ID: LDA0007518
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:MEG3
Full Name:maternally expressed 3
Category:LncRNA
Species:Homo sapiens
Synonyms:FP504|GTL2|LINC00023|NCRNA00023|PRO0518|PRO2160|onco-lncRNA-83|prebp1
Chromosome:14
Strand:+
Coordinate:
Start Site(bp):100826108End Site(bp):100861026
External Links:
Ensembl ID:ENSG00000214548
Ensembl Transcript ID:ENSG00000214548
Entrez Gene:55384.0
NONCODE ID:N/A
RefSeq Accession:NR_003531.3

 

ncRNA Association Statistics

Total Associated Disease Number:114   
More Information
Causal Disease Number:78
Network:
Top Causal Diseases:
Stomach Neoplasms  (Score: 1)
Carcinoma, Non-Small-Cell Lung  (Score: 1)
Carcinoma, Hepatocellular  (Score: 1)
Sepsis  (Score: 1)
Glioma  (Score: 1)
Breast Neoplasms  (Score: 1)
Carcinoma, Non-Small-Cell Lung  (Score: 1)
Sepsis  (Score: 1)
Carcinoma, Hepatocellular  (Score: 1)
Breast Neoplasms  (Score: 1)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:0050861
Disease Name:colorectal adenocarcinoma
Category:Disease Ontology
Type:Neoplasms
Define:A colorectal carcinoma that derives_from epithelial cells of glandular origin.
Alias:

 

Disease Association Statistics

Total Associated ncRNA Number:16   
More Information
Causal ncRNA Number:10
Network:
Top Causal ncRNAs:
AK077216  (Score: 0.731059)
AWPPH  (Score: 0.731059)
PCED1B-AS1  (Score: 0.731059)
MNX1-AS1  (Score: 0.731059)
MEG3  (Score: 0.731059)
AK077216  (Score: 0.731059)
AWPPH  (Score: 0.731059)
PCED1B-AS1  (Score: 0.731059)
MNX1-AS1  (Score: 0.731059)
MEG3  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:CCK8//qRT-PCR//MTT//Western Blot
Weak Evidence:

 

Reference

[1] PubMed ID:30556866
Disease Name:colorectal adenocarcinoma
Sample:tumor tissues,Serum
Dysfunction Pattern:Regulation[TGF-β1,sphingosine kinase 1]
Validated Method:CCK8//qRT-PCR//MTT//Western Blot
Description:MEG3 expression level was decreased in tumor tissues than that in adjacent healthy tissues. Serum level of MEG3 was lower in cancer patients than that in healthy controls, and the serum level decreased with the increased stage of primary tumor. Downregulation of lncRNA MEG3 can promote colorectal adenocarcinoma cell proliferation and inhibit the apoptosis by up-regulating TGF-β1 and its downstream sphingosine kinase 1.
Causality:Yes
Causal Description: MEG3 knockdown and SPHK1 overexpression promoted tumor cell proliferation, but inhibited cell apoptosis.
Clinical-realted Application: