Entry Detail

General Information

Database ID: LDA0007529
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:MEG3
Full Name:maternally expressed 3
Category:LncRNA
Species:Homo sapiens
Synonyms:FP504|GTL2|LINC00023|NCRNA00023|PRO0518|PRO2160|onco-lncRNA-83|prebp1
Chromosome:14
Strand:+
Coordinate:
Start Site(bp):100826108End Site(bp):100861026
External Links:
Ensembl ID:ENSG00000214548
Ensembl Transcript ID:ENSG00000214548
Entrez Gene:55384.0
NONCODE ID:N/A
RefSeq Accession:NR_003531.3

 

ncRNA Association Statistics

Total Associated Disease Number:114   
More Information
Causal Disease Number:78
Network:
Top Causal Diseases:
Stomach Neoplasms  (Score: 1)
Carcinoma, Non-Small-Cell Lung  (Score: 1)
Carcinoma, Hepatocellular  (Score: 1)
Sepsis  (Score: 1)
Glioma  (Score: 1)
Breast Neoplasms  (Score: 1)
Carcinoma, Non-Small-Cell Lung  (Score: 1)
Sepsis  (Score: 1)
Carcinoma, Hepatocellular  (Score: 1)
Breast Neoplasms  (Score: 1)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:255D006391
Disease Name:hemangiomaHemangioma
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A cardiovascular organ benign neoplasm that has_material_basis_in endothelial cells that line blood vessels and is characterised by increased number of normal or abnormal vessels filled with blood.A vascular anomaly due to proliferation of BLOOD VESSELS that forms a tumor-like mass. The common types involve CAPILLARIES and VEINS. It can occur anywhere in the body but is most frequently noticed in the SKIN and SUBCUTANEOUS TISSUE. (from Stedman, 27th ed, 2000)
Alias:Hemangioma//Hemangiomas//Hemangioma, Intramuscular//Hemangiomas, Intramuscular//Intramuscular Hemangioma//Intramuscular Hemangiomas//Hemangioma, Histiocytoid//Hemangiomas, Histiocytoid//Histiocytoid Hemangioma//Histiocytoid Hemangiomas//Angioma//Chorioangioma//Chorioangiomas//Chorangioma//Chorangiomas

 

Disease Association Statistics

Total Associated ncRNA Number:12   
More Information
Causal ncRNA Number:12
Network:
Top Causal ncRNAs:
circAP2A2  (Score: 0.731059)
NEAT1  (Score: 0.731059)
MEG3  (Score: 0.731059)
MEG8  (Score: 0.731059)
OIP5-AS1  (Score: 0.731059)
MCM3AP-AS1  (Score: 0.731059)
circAP2A2  (Score: 0.731059)
NEAT1  (Score: 0.731059)
MEG3  (Score: 0.731059)
MEG8  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:Western Blot//Flow Cytometry//qRT-PCR//RIP//MTT//Luciferase Report Assay//Colony Formation Assay
Weak Evidence:

 

Reference

[1] PubMed ID:30562741
Disease Name:Hemangioma
Sample:involuting phase HAs and normal skin tissues
Dysfunction Pattern:Regulation[miR-494 and regulating PTEN/PI3K/AKT pathway]
Validated Method:Western Blot//Flow Cytometry//qRT-PCR//RIP//MTT//Luciferase Report Assay//Colony Formation Assay
Description: The expression of MEG3 was substantially decreased and had a negative correlation with VEGF expression in proliferating phase HAs, as compared with the involuting phase HAs and normal skin tissues.Our findings suggested that lncRNA MEG3 inhibited HAs tumorigenesis by sponging miR-494 and regulating PTEN/PI3K/AKT pathway.
Causality:Yes
Causal Description:Ectopic expression of MEG3 suppressed cell proliferation, colony formation and induced cycle arrest in vitro and in vivo, followed by the downregulation of VEGF and cyclinD1, but knockdown of MEG3 reversed these effects.
Clinical-realted Application: