Entry Detail

General Information

Database ID: LDA0007553
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:MIAT
Full Name:myocardial infarction associated transcript
Category:LncRNA
Species:Homo sapiens
Synonyms:C22orf35|GOMAFU|LINC00066|NCRNA00066|RNCR2|lncRNA-MIAT
Chromosome:22
Strand:+
Coordinate:
Start Site(bp):26657482End Site(bp):26676478
External Links:
Ensembl ID:ENSG00000225783
Ensembl Transcript ID:N/A
Entrez Gene:440823.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:66   
More Information
Causal Disease Number:52
Network:
Top Causal Diseases:
Breast Neoplasms  (Score: 0.999998)
Breast Neoplasms  (Score: 0.999998)
Stomach Neoplasms  (Score: 0.999893)
Carcinoma, Hepatocellular  (Score: 0.999893)
Carcinoma, Hepatocellular  (Score: 0.999893)
Stomach Neoplasms  (Score: 0.999893)
Thyroid Cancer, Papillary  (Score: 0.985791)
Diabetic Nephropathies  (Score: 0.985791)
acute myocardial infarction  (Score: 0.985791)
Uterine Cervical Neoplasms  (Score: 0.985791)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:D002340
Disease Name:Carotid Artery Diseases
Category:MeSH
Type:Nervous System Diseases
Define:Pathological conditions involving the CAROTID ARTERIES, including the common, internal, and external carotid arteries. ATHEROSCLEROSIS and TRAUMA are relatively frequent causes of carotid artery pathology.
Alias:Carotid Artery Diseases//Artery Disease, Carotid//Artery Diseases, Carotid//Carotid Artery Disease//Carotid Artery Disorders//Artery Disorder, Carotid//Artery Disorders, Carotid//Carotid Artery Disorder//Disorders, Carotid Artery//Arterial Diseases, Carotid//Arterial Disease, Carotid//Carotid Arterial Disease//Carotid Arterial Diseases//Carotid Atherosclerosis//Carotid Atheroscleroses//Carotid Atherosclerotic Disease//Atherosclerotic Disease, Carotid//Atherosclerotic Diseases, Carotid//Carotid Atherosclerotic Diseases//Internal Carotid Artery Diseases//Arterial Diseases, Internal Carotid//Internal Carotid Artery Disease//Arterial Diseases, Common Carotid//Common Carotid Artery Diseases//Common Carotid Artery Disease//External Carotid Artery Diseases//Arterial Diseases, External Carotid

 

Disease Association Statistics

Total Associated ncRNA Number:2   
More Information
Causal ncRNA Number:2
Network:
Top Causal ncRNAs:
MIAT  (Score: 0.731059)
MIAT  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:ISH//Transfection//Immunoblotting//Migration Assay//RIP//Cell Apoptosis Assay//Cell Proliferation Assay//IHC//IF
Weak Evidence:

 

Reference

[1] PubMed ID:34647815
Disease Name:Carotid Artery Diseases
Sample:
Dysfunction Pattern:Interaction(KLF4 )
Validated Method:ISH//Transfection//Immunoblotting//Migration Assay//RIP//Cell Apoptosis Assay//Cell Proliferation Assay//IHC//IF
Description:MIAT mechanistically regulated SMC proliferation through the EGR1 (Early Growth Response 1)-ELK1 (ETS Transcription Factor ELK1)-ERK (Extracellular Signal-Regulated Kinase) pathway. MIAT is further involved in SMC phenotypic transition to proinflammatory macrophage-like cells through binding to the promoter region of KLF4 and enhancing its transcription.
Causality:Yes
Causal Description:Experimental knockdown of MIAT, using site-specific antisense oligonucleotides (LNA-GapmeRs) not only markedly decreased proliferation and migration rates of cultured human carotid artery smooth muscle cells (SMCs) but also increased their apoptosis. Studies using Miat-/- and Miat-/-ApoE-/- mice, and Yucatan LDLR-/- mini-pigs, as well, confirmed the regulatory role of this lncRNA in SMC de- and transdifferentiation and advanced atherosclerotic lesion formation.
Clinical-realted Application: