Entry Detail

General Information

Database ID: LDA0007588
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:OIP5-AS1
Full Name:OIP5 antisense RNA 1
Category:LncRNA
Species:Homo sapiens
Synonyms:cyrano|linc-OIP5
Chromosome:15
Strand:+
Coordinate:
Start Site(bp):41282697End Site(bp):41313338
External Links:
Ensembl ID:ENSG00000247556
Ensembl Transcript ID:N/A
Entrez Gene:729082.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:68   
More Information
Causal Disease Number:62
Network:
Top Causal Diseases:
Breast Neoplasms  (Score: 1)
Uterine Cervical Neoplasms  (Score: 1)
Breast Neoplasms  (Score: 1)
Stomach Neoplasms  (Score: 1)
Uterine Cervical Neoplasms  (Score: 1)
Stomach Neoplasms  (Score: 1)
Lung Neoplasms  (Score: 0.999893)
Lung Neoplasms  (Score: 0.999893)
Osteosarcoma  (Score: 0.985791)
Squamous Cell Carcinoma of Head and Neck  (Score: 0.985791)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:824D010518
Disease Name:periodontitisPeriodontitis
Category:Disease OntologyMeSH
Type:Stomatognathic Diseases
Define:Inflammation and loss of connective tissues supporting or surrounding the teeth. This may involve any part of the PERIODONTIUM. Periodontitis is currently classified by disease progression (CHRONIC PERIODONTITIS; AGGRESSIVE PERIODONTITIS) instead of age of onset. (From 1999 International Workshop for a Classification of Periodontal Diseases and Conditions, American Academy of Periodontology)
Alias:chronic pericementitisPeriodontitis//Periodontitides//Pericementitis//Pericementitides

 

Disease Association Statistics

Total Associated ncRNA Number:22   
More Information
Causal ncRNA Number:8
Network:
Top Causal ncRNAs:
hsa_circ_0138959  (Score: 0.731059)
hsa_circ_0099630  (Score: 0.731059)
OIP5-AS1  (Score: 0.731059)
Nron  (Score: 0.731059)
hsa_circ_0138959  (Score: 0.731059)
hsa_circ_0099630  (Score: 0.731059)
OIP5-AS1  (Score: 0.731059)
Nron  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:Western Blot//Transfection//qRT-PCR//RIP//MTT//Luciferase Report Assay
Weak Evidence:

 

Reference

[1] PubMed ID:35546327
Disease Name:Periodontitis
Sample:human periodontal ligament stem cells (hPDLSCs)
Dysfunction Pattern:Interaction(miR-92a-3p)
Validated Method:Western Blot//Transfection//qRT-PCR//RIP//MTT//Luciferase Report Assay
Description:We found that OIP5-AS1 was expressed at low levels in lipopolysaccharide (LPS)-stimulated hPDLSCs. OIP5-AS1 overexpression promoted proliferation and osteogenic differentiation ability and reduced LPS-induced inflammation in hPDLSCs. Furthermore, OIP5-AS1 directly targeted and reduced miR-92a-3p expression. The overexpression of miR-92a-3p partly abolished the effects of OIP5-AS1 on LPS-induced cell proliferation and osteogenic differentiation as well as inflammation in hPDLSCs. Collectively, the results indicated that OIP5-AS1 overexpression inhibited the LPS-induced inflammatory response and promoted the osteogenic differentiation of hPDLSCs by sponging miR-92a-3p. Thus, OIP5-AS1 is probably an essential objective for research during periodontitis treatment.
Causality:Yes
Causal Description:OIP5-AS1 overexpression promoted proliferation and osteogenic differentiation ability and reduced LPS-induced inflammation in hPDLSCs.
Clinical-realted Application: