Entry Detail

General Information

Database ID: LDA0007594
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:OIP5-AS1
Full Name:OIP5 antisense RNA 1
Category:LncRNA
Species:Homo sapiens
Synonyms:cyrano|linc-OIP5
Chromosome:15
Strand:+
Coordinate:
Start Site(bp):41282697End Site(bp):41313338
External Links:
Ensembl ID:ENSG00000247556
Ensembl Transcript ID:N/A
Entrez Gene:729082.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:68   
More Information
Causal Disease Number:62
Network:
Top Causal Diseases:
Breast Neoplasms  (Score: 1)
Uterine Cervical Neoplasms  (Score: 1)
Breast Neoplasms  (Score: 1)
Stomach Neoplasms  (Score: 1)
Uterine Cervical Neoplasms  (Score: 1)
Stomach Neoplasms  (Score: 1)
Lung Neoplasms  (Score: 0.999893)
Lung Neoplasms  (Score: 0.999893)
Osteosarcoma  (Score: 0.985791)
Squamous Cell Carcinoma of Head and Neck  (Score: 0.985791)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:687D018197
Disease Name:hepatoblastomaHepatoblastoma
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A malignant neoplasm occurring in young children, primarily in the liver, composed of tissue resembling embryonal or fetal hepatic epithelium, or mixed epithelial and mesenchymal tissues. (Stedman, 25th ed)
Alias:Hepatoblastoma//Hepatoblastomas

 

Disease Association Statistics

Total Associated ncRNA Number:36   
More Information
Causal ncRNA Number:30
Network:
Top Causal ncRNAs:
ZFAS1  (Score: 0.731059)
LINC00205  (Score: 0.731059)
GAS5  (Score: 0.731059)
LUCAT1  (Score: 0.731059)
LINC01023  (Score: 0.731059)
circHMGCS1  (Score: 0.731059)
circSETD3  (Score: 0.731059)
hsa_circ_0000594  (Score: 0.731059)
OIP5-AS1  (Score: 0.731059)
MIR210HG  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:In Vivo Experiment//Western Blot//Transwell Assay//Transfection//Wound Healing Assay//Colony Formation Assay//RIP//qRT-PCR//IHC//IF
Weak Evidence:

 

Reference

[1] PubMed ID:35255389
Disease Name:Hepatoblastoma
Sample:hepatoblastoma cells
Dysfunction Pattern:Interaction(PTBP1/ β-catenin )
Validated Method:In Vivo Experiment//IHC//Western Blot//Transfection//Wound Healing Assay//RIP//qRT-PCR//IF//Colony Formation Assay//Transwell Assay
Description: OIP5-AS1 was significantly up-regulated in hepatoblastoma cells. OIP5-AS1 bound with PTBP1, and silencing of OIP5-AS1 inhibited β-catenin. Meanwhile, overexpression of PTBP1 or β-catenin activation significantly reversed OIP5-AS1 silencing-inhibited hepatoblastoma cell proliferation and stemness. Moreover, β-catenin was found to be the downstream target of PTBP1, and OIP5-AS1 activated β-catenin signaling via promoting the binding between PTBP1 and β-catenin to increase the mRNA stability of β-catenin.
Causality:Yes
Causal Description:OIP5-AS1 silencing notably attenuated the stemness and invasion of hepatoblastoma cells. Finally, OIP5-AS1 knockdown significantly alleviated the tumor growth of hepatoblastoma by repressing β-catenin.
Clinical-realted Application: