Entry Detail

General Information

Database ID: LDA0007627
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:OIP5-AS1
Full Name:OIP5 antisense RNA 1
Category:LncRNA
Species:Homo sapiens
Synonyms:cyrano|linc-OIP5
Chromosome:15
Strand:+
Coordinate:
Start Site(bp):41282697End Site(bp):41313338
External Links:
Ensembl ID:ENSG00000247556
Ensembl Transcript ID:N/A
Entrez Gene:729082.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:68   
More Information
Causal Disease Number:62
Network:
Top Causal Diseases:
Breast Neoplasms  (Score: 1)
Uterine Cervical Neoplasms  (Score: 1)
Breast Neoplasms  (Score: 1)
Stomach Neoplasms  (Score: 1)
Uterine Cervical Neoplasms  (Score: 1)
Stomach Neoplasms  (Score: 1)
Lung Neoplasms  (Score: 0.999893)
Lung Neoplasms  (Score: 0.999893)
Osteosarcoma  (Score: 0.985791)
Squamous Cell Carcinoma of Head and Neck  (Score: 0.985791)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:3498
Disease Name:pancreatic ductal adenocarcinoma
Category:Disease Ontology
Type:Neoplasms
Define:A pancreatic adenocarcinoma that derives_from pancreatic duct cells.
Alias:ductal adenocarcinoma of the pancreas

 

Disease Association Statistics

Total Associated ncRNA Number:178   
More Information
Causal ncRNA Number:110
Network:
Top Causal ncRNAs:
NEAT1  (Score: 0.985791)
NEAT1  (Score: 0.985791)
circMYOF  (Score: 0.731059)
circBFAR  (Score: 0.731059)
hsa_circ_000684  (Score: 0.731059)
circSLIT2  (Score: 0.731059)
hsa_circ_0005105  (Score: 0.731059)
circEYA3  (Score: 0.731059)
circNEIL3  (Score: 0.731059)
hsa_circ_0047744  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:qRT-PCR//Luciferase Report Assay//RNA Pull-Down
Weak Evidence:

 

Reference

[1] PubMed ID:32669972
Disease Name:pancreatic ductal adenocarcinoma
Sample:PDAC tissues and cell lines
Dysfunction Pattern:regulation[miR-429/FOXD1/ERK pathway]
Validated Method:qRT-PCR//RNA Pull-Down//Luciferase Report Assay
Description:OIP5-AS1 was up-regulated in PDAC tissues and cell lines, and high level of OIP5-AS1 indicated poor prognosis in PDAC patients.OIP5-AS1 exerted oncogenic function in PDAC cells through targeting miR-429/FOXD1/ERK pathway.
Causality:Yes
Causal Description:OIP5-AS1 knockdown hindered cell proliferation, migration and epithelial-mesenchymal transition (EMT) process, while overexpression of OIP5-AS1 caused the opposite results.
Clinical-realted Application:OIP5-AS1 was up-regulated in PDAC tissues and cell lines, and high level of OIP5-AS1 indicated poor prognosis in PDAC patients.