Entry Detail

General Information

Database ID: LDA0007631
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:OIP5-AS1
Full Name:OIP5 antisense RNA 1
Category:LncRNA
Species:Homo sapiens
Synonyms:cyrano|linc-OIP5
Chromosome:15
Strand:+
Coordinate:
Start Site(bp):41282697End Site(bp):41313338
External Links:
Ensembl ID:ENSG00000247556
Ensembl Transcript ID:N/A
Entrez Gene:729082.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:68   
More Information
Causal Disease Number:62
Network:
Top Causal Diseases:
Breast Neoplasms  (Score: 1)
Uterine Cervical Neoplasms  (Score: 1)
Breast Neoplasms  (Score: 1)
Stomach Neoplasms  (Score: 1)
Uterine Cervical Neoplasms  (Score: 1)
Stomach Neoplasms  (Score: 1)
Lung Neoplasms  (Score: 0.999893)
Lung Neoplasms  (Score: 0.999893)
Osteosarcoma  (Score: 0.985791)
Squamous Cell Carcinoma of Head and Neck  (Score: 0.985791)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:255D006391
Disease Name:hemangiomaHemangioma
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A cardiovascular organ benign neoplasm that has_material_basis_in endothelial cells that line blood vessels and is characterised by increased number of normal or abnormal vessels filled with blood.A vascular anomaly due to proliferation of BLOOD VESSELS that forms a tumor-like mass. The common types involve CAPILLARIES and VEINS. It can occur anywhere in the body but is most frequently noticed in the SKIN and SUBCUTANEOUS TISSUE. (from Stedman, 27th ed, 2000)
Alias:Hemangioma//Hemangiomas//Hemangioma, Intramuscular//Hemangiomas, Intramuscular//Intramuscular Hemangioma//Intramuscular Hemangiomas//Hemangioma, Histiocytoid//Hemangiomas, Histiocytoid//Histiocytoid Hemangioma//Histiocytoid Hemangiomas//Angioma//Chorioangioma//Chorioangiomas//Chorangioma//Chorangiomas

 

Disease Association Statistics

Total Associated ncRNA Number:12   
More Information
Causal ncRNA Number:12
Network:
Top Causal ncRNAs:
circAP2A2  (Score: 0.731059)
NEAT1  (Score: 0.731059)
MEG3  (Score: 0.731059)
MEG8  (Score: 0.731059)
OIP5-AS1  (Score: 0.731059)
MCM3AP-AS1  (Score: 0.731059)
circAP2A2  (Score: 0.731059)
NEAT1  (Score: 0.731059)
MEG3  (Score: 0.731059)
MEG8  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:Western Blot//Flow Cytometry//qRT-PCR//FISH//RIP//MTT
Weak Evidence:

 

Reference

[1] PubMed ID:31068824
Disease Name:Hemangioma
Sample:hemangioma tissues,cell lines
Dysfunction Pattern:Regulation[miR-195-5p/NOB1 Axis]
Validated Method:Western Blot//Flow Cytometry//qRT-PCR//RIP//FISH//MTT
Description: It was found that OIP5-AS1 was overexpressed in both hemangioma tissues and HemECs cells. Taken together, lncRNA OIP5-AS1 acted as a ceRNA to drive proliferation, migration and invasion of HemECs through regulating miR-195-5p/NOB1 axis.
Causality:Yes
Causal Description: OIP5-AS1 knockdown suppressed the proliferation, migration, and invasion of HemECs cell, while overexpression of OIP5-AS1 had opposite effects LncRNA OIP5-AS1 acted as a ceRNA through binding with miR-195-5p to upregulate NOB1 in HemECs.
Clinical-realted Application: