Entry Detail

General Information

Database ID: LDA0007638
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:NALT1
Full Name:NOTCH1 associated lncRNA in T cell acute lymphoblastic leukemia 1
Category:LncRNA
Species:Homo sapiens
Synonyms:LINC01573|MIR4674HG|NALT|TCONS_l2_00029132
Chromosome:9
Strand:+
Coordinate:
Start Site(bp):136547842End Site(bp):136549744
External Links:
Ensembl ID:ENSG00000237886
Ensembl Transcript ID:N/A
Entrez Gene:101928483.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:4   
More Information
Causal Disease Number:2
Network:
Top Causal Diseases:
Colorectal Neoplasms  (Score: 0.731059)
Colorectal Neoplasms  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:9256D015179
Disease Name:colorectal cancerColorectal Neoplasms
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A large intestine cancer that is located_in the colon and/or located_in the rectum.Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI.
Alias:Colorectal Neoplasms//Colorectal Neoplasm//Neoplasm, Colorectal//Neoplasms, Colorectal//Colorectal Tumors//Colorectal Tumor//Tumor, Colorectal//Tumors, Colorectal//Colorectal Cancer//Cancer, Colorectal//Cancers, Colorectal//Colorectal Cancers//Colorectal Carcinoma//Carcinoma, Colorectal//Carcinomas, Colorectal//Colorectal Carcinomas

 

Disease Association Statistics

Total Associated ncRNA Number:1274   
More Information
Causal ncRNA Number:984
Network:
Top Causal ncRNAs:
TP73-AS1  (Score: 1)
PVT1  (Score: 1)
UCA1  (Score: 1)
TUG1  (Score: 1)
ZFAS1  (Score: 1)
XIST  (Score: 1)
SNHG6  (Score: 1)
MEG3  (Score: 1)
HOTTIP  (Score: 1)
MCM3AP-AS1  (Score: 1)
More Information

 

Evidence Support

Strong Evidence:qRT-PCR//RNA Pull-Down
Weak Evidence:

 

Reference

[1] PubMed ID:36385135
Disease Name:Colorectal Neoplasms
Sample:76 CRC patients and CRC cell line
Dysfunction Pattern:Interaction(miRNA-574-5p/PEG10 )
Validated Method:qRT-PCR//RNA Pull-Down
Description: It was observed that high expression of NALT1 was markedly correlated with advanced cancer stage in the clinic. Bioinformatics analysis, RNA pulldown, Ago2-RIP, and luciferase reporter assays showed that miRNA-574-5p was a target of NALT1. Additionally, dual-luciferase reporter assays, Ago2-RIP, and rescue experiments indicated that miRNA-574-5p could target the PEG10 gene directly.
Causality:Yes
Causal Description: Functionally, NALT1 downregulation inhibited cell proliferation, migration and invasion, whereas NALT1 overexpression exhibited an opposite trend both in vivo and in vitro.
Clinical-realted Application:It was observed that high expression of NALT1 was markedly correlated with advanced cancer stage in the clinic.