Entry Detail

General Information

Database ID: LDA0007660
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:METTL3
Full Name:glycoprotein M6A
Category:LncRNA
Species:Homo sapiens
Synonyms:GPM6|M6A
Chromosome:4
Strand:-
Coordinate:
Start Site(bp):175632937End Site(bp):176002691
External Links:
Ensembl ID:ENSG00000165819
Ensembl Transcript ID:N/A
Entrez Gene:2823.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:6   
More Information
Causal Disease Number:6
Network:
Top Causal Diseases:
Carcinoma, Non-Small-Cell Lung  (Score: 0.731059)
Colorectal Neoplasms  (Score: 0.731059)
Triple Negative Breast Neoplasms  (Score: 0.731059)
Carcinoma, Non-Small-Cell Lung  (Score: 0.731059)
Colorectal Neoplasms  (Score: 0.731059)
Triple Negative Breast Neoplasms  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:9256D015179
Disease Name:colorectal cancerColorectal Neoplasms
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A large intestine cancer that is located_in the colon and/or located_in the rectum.Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI.
Alias:Colorectal Neoplasms//Colorectal Neoplasm//Neoplasm, Colorectal//Neoplasms, Colorectal//Colorectal Tumors//Colorectal Tumor//Tumor, Colorectal//Tumors, Colorectal//Colorectal Cancer//Cancer, Colorectal//Cancers, Colorectal//Colorectal Cancers//Colorectal Carcinoma//Carcinoma, Colorectal//Carcinomas, Colorectal//Colorectal Carcinomas

 

Disease Association Statistics

Total Associated ncRNA Number:1274   
More Information
Causal ncRNA Number:984
Network:
Top Causal ncRNAs:
TP73-AS1  (Score: 1)
PVT1  (Score: 1)
UCA1  (Score: 1)
TUG1  (Score: 1)
ZFAS1  (Score: 1)
XIST  (Score: 1)
SNHG6  (Score: 1)
MEG3  (Score: 1)
HOTTIP  (Score: 1)
MCM3AP-AS1  (Score: 1)
More Information

 

Evidence Support

Strong Evidence:colony Formation Assay//IHC//ChIP//TUNEL//Western Blot//ISH//Wound Healing Assay//Tunel//qRT-PCR//RIP//FISH//MSP//PCR//IP//Colony Formation Assay//Invasion Assay//IF
Weak Evidence:

 

Reference

[1] PubMed ID:35710754
Disease Name:Colorectal Neoplasms
Sample:CRC tissues and cells
Dysfunction Pattern:Interaction(miR-107/PER3 axis)
Validated Method:colony Formation Assay//TUNEL//Western Blot//ISH//Wound Healing Assay//Tunel//Colony Formation Assay//qRT-PCR//RIP//FISH//IF//MSP//PCR//IP//IHC//Invasion Assay//ChIP
Description:RUNX3, circMETTL3, and PER3 were diminished while miR-107 was elevated in CRC tissues and cells. Mechanistically, RUNX3 bound to METTL3 promoter and activated circMETTL3 transcription. circMETTL3 directly bound with miR-107 which targeted PER3. circMETTL3/miR-107 regulated CRC cell proliferation and invasion via PER3. CircMETTL3, transcriptionally activated by RUNX3, restrains CRC development and metastasis via acting as a miR-107 sponge to regulate PER3 signaling.
Causality:Yes
Causal Description:Overexpression of RUNX3, circMETTL3, or PER3 suppressed while miR-107 mimics promoted, CRC cell proliferation and invasion, as well as tumor growth and metastasis in vivo.
Clinical-realted Application:Low levels of RUNX3 and circMETTL3 correlated with poor prognosis of CRC.