Entry Detail

General Information

Database ID: LDA0007687
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:NRAD1
Full Name:non-coding RNA in the aldehyde dehydrogenase 1A pathway
Category:LncRNA
Species:Homo sapiens
Synonyms:LINC00284|NCRNA00284
Chromosome:13
Strand:+
Coordinate:
Start Site(bp):44022335End Site(bp):44030463
External Links:
Ensembl ID:ENSG00000233725
Ensembl Transcript ID:N/A
Entrez Gene:121838.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:10   
More Information
Causal Disease Number:10
Network:
Top Causal Diseases:
Intervertebral Disc Degeneration  (Score: 0.731059)
Thyroid Cancer, Papillary  (Score: 0.731059)
Thyroid Neoplasms  (Score: 0.731059)
Colorectal Neoplasms  (Score: 0.731059)
Lung Neoplasms  (Score: 0.731059)
Intervertebral Disc Degeneration  (Score: 0.731059)
Thyroid Cancer, Papillary  (Score: 0.731059)
Thyroid Neoplasms  (Score: 0.731059)
Colorectal Neoplasms  (Score: 0.731059)
Lung Neoplasms  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:90D055959
Disease Name:degenerative disc diseaseIntervertebral Disc Degeneration
Category:Disease OntologyMeSH
Type:Musculoskeletal Diseases
Define:A bone deterioration disease that has_material_basis_in gradual dehydration and tears located_in intervertebral disc.Degenerative changes in the INTERVERTEBRAL DISC due to aging or structural damage, especially to the vertebral end-plates.
Alias:cervical disc degenerative disease//intervertebral disc degeneration//lumbar disc degeneration//vertebral disc diseaseIntervertebral Disc Degeneration//Degeneration, Intervertebral Disc//Disc Degeneration, Intervertebral//Intervertebral Disc Degenerations//Disc Degeneration//Degeneration, Disc//Disc Degenerations//Intervertebral Disk Degeneration//Degeneration, Intervertebral Disk//Disk Degeneration, Intervertebral//Intervertebral Disk Degenerations//Disk Degeneration//Degeneration, Disk//Disk Degenerations//Disk Degradation//Degradation, Disk//Disk Degradations//Degenerative Disc Disease//Degenerative Disc Diseases//Disc Disease, Degenerative//Disc Degradation//Degradation, Disc//Disc Degradations//Degenerative Intervertebral Discs//Degenerative Intervertebral Disc//Disc, Degenerative Intervertebral//Intervertebral Disc, Degenerative//Degenerative Intervertebral Disks//Degenerative Intervertebral Disk//Disk, Degenerative Intervertebral//Intervertebral Disk, Degenerative

 

Disease Association Statistics

Total Associated ncRNA Number:20   
More Information
Causal ncRNA Number:14
Network:
Top Causal ncRNAs:
ITCH  (Score: 0.731059)
MALAT1  (Score: 0.731059)
CAHM  (Score: 0.731059)
PART1  (Score: 0.731059)
RMRP  (Score: 0.731059)
circGLCE  (Score: 0.731059)
NRAD1  (Score: 0.731059)
ITCH  (Score: 0.731059)
MALAT1  (Score: 0.731059)
CAHM  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:In Vivo Experiment//Western Blot//qRT-PCR//Luciferase Report Assay//Cell Apoptosis Assay//Cell Proliferation Assay
Weak Evidence:

 

Reference

[1] PubMed ID:35322864
Disease Name:Intervertebral Disc Degeneration
Sample:IDD tissue and NP cells
Dysfunction Pattern:Interaction(miR‑205‑3p/Wnt/β‑catenin axis)
Validated Method:In Vivo Experiment//Western Blot//qRT-PCR//Luciferase Report Assay//Cell Apoptosis Assay//Cell Proliferation Assay
Description: The results showed that LINC00284 expression was upregulated in IDD tissue and IL?1β?induced NP cells. LINC00284 was also shown to be a target of microRNA (miR)‑205‑3p, and there was a negative correlation between LINC00284 and miR‑205‑3p levels in IDD tissue. Additionally, LINC00284 knockdown or miR‑205‑3p upregulation resulted in inhibition of Wnt/β‑catenin signaling and subsequent degradation of the ECM.
Causality:Yes
Causal Description: LINC00284 knockdown resulted in an increase in IL‑1β‑induced NP cell proliferation, a decrease in apoptosis and matrix metalloproteinase‑3 expression and an increase in expression of extracellular matrix (ECM) markers aggrecan and collagen II. In vivo experiments and histomorphometric analysis confirmed the protective effect of LINC00284 knockdown in IDD.
Clinical-realted Application: