Entry Detail

General Information

Database ID: LDA0007710
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:MEG8
Full Name:maternally expressed 8, small nucleolar RNA host gene
Category:LncRNA
Species:Homo sapiens
Synonyms:Bsr|Irm|LINC00024|NCRNA00024|Rian|SNHG23|SNHG24|lnc-MGC
Chromosome:14
Strand:+
Coordinate:
Start Site(bp):100889649End Site(bp):100999113
External Links:
Ensembl ID:ENSG00000225746
Ensembl Transcript ID:N/A
Entrez Gene:79104.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:16   
More Information
Causal Disease Number:14
Network:
Top Causal Diseases:
Carcinoma, Non-Small-Cell Lung  (Score: 0.985791)
Carcinoma, Non-Small-Cell Lung  (Score: 0.985791)
Hemangioma  (Score: 0.731059)
Carcinoma, Hepatocellular  (Score: 0.731059)
Carcinoma, Renal Cell  (Score: 0.731059)
Wilms Tumor  (Score: 0.731059)
Myocardial Reperfusion Injury  (Score: 0.731059)
Bone-Invasive Pituitary Adenomas  (Score: 0.731059)
Hemangioma  (Score: 0.731059)
Carcinoma, Hepatocellular  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:2154D009396
Disease Name:nephroblastomaWilms Tumor
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A kidney cancer that affects the kidneys and typically located_in children.A malignant kidney tumor, caused by the uncontrolled multiplication of renal stem (blastemal), stromal (STROMAL CELLS), and epithelial (EPITHELIAL CELLS) elements. However, not all three are present in every case. Several genes or chromosomal areas have been associated with Wilms tumor which is usually found in childhood as a firm lump in a child's side or ABDOMEN.
Alias:adult nephroblastomaWilms Tumor//Tumor, Wilms//Wilms' Tumor//Tumor, Wilms'//Wilm Tumor//Wilm's Tumor//Wilms Tumor 1//Nephroblastoma//Nephroblastomas//Bilateral Wilms Tumor//Tumor, Bilateral Wilms//Wilms Tumor, Bilateral

 

Disease Association Statistics

Total Associated ncRNA Number:36   
More Information
Causal ncRNA Number:34
Network:
Top Causal ncRNAs:
XIST  (Score: 0.985791)
XIST  (Score: 0.985791)
OSTM1-AS1  (Score: 0.731059)
SOX21-AS1  (Score: 0.731059)
circNCKAP1  (Score: 0.731059)
CRNDE  (Score: 0.731059)
H19  (Score: 0.731059)
HAGLROS  (Score: 0.731059)
hsa_circ_0093741  (Score: 0.731059)
DLEU2  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:Western Blot//Transfection//Wound Healing Assay//qRT-PCR//MTT//Transwell Assay
Weak Evidence:

 

Reference

[1] PubMed ID:34518485
Disease Name:Wilms Tumor
Sample:WT tissues and cells
Dysfunction Pattern:Interaction(miR-23a-3p/CRK Axis)
Validated Method:Western Blot//Transfection//Wound Healing Assay//qRT-PCR//MTT//Transwell Assay
Description:MEG8 and CRK expression was elevated, while miR-23a-3p expression was decreased in WT tissues and cells. . As to mechanism exploration, MEG8 could directly bind to miR-23a-3p and then miR-23a-3p targeted CRK. MEG8 was inversely correlated with miR-23a-3p and positively correlated with CRK in WT tissues. Meantime, miR-23a-3p was inversely correlated with CRK in WT tissues.
Causality:Yes
Causal Description: MEG8 knockdown or miR-23a-3p overexpression restrained WT cells in cell viability, migration, and invasiveness in vitro. Additionally, MEG8 knockdown-mediated suppressive impacts on cell viability, migration, and invasiveness were reversed by overexpression of CRK or repression of miR-23a-3p in WT cells.
Clinical-realted Application:. The histologic type, lymphatic metastasis, and National Wilms Tumor Study (NWTS) stage were associated with the expression of MEG8, miR-23a-3p, and CRK in WT patients.