Entry Detail

General Information

Database ID: LDA0007726
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:NT5E
Full Name:5'-nucleotidase ecto
Category:LncRNA
Species:Homo sapiens
Synonyms:CALJA|CD73|E5NT|NT|NT5|NTE|eN|eNT
Chromosome:6
Strand:+
Coordinate:
Start Site(bp):85450083End Site(bp):85495784
External Links:
Ensembl ID:ENSG00000135318
Ensembl Transcript ID:N/A
Entrez Gene:4907.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:2   
More Information
Causal Disease Number:2
Network:
Top Causal Diseases:
Pancreatic Neoplasms  (Score: 0.731059)
Pancreatic Neoplasms  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:1793D010190
Disease Name:pancreatic cancerPancreatic Neoplasms
Category:Disease OntologyMeSH
Type:Neoplasms
Define:An endocrine gland cancer located_in the pancreas.Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).
Alias:Ca body of pancreas//Ca head of pancreas//Ca tail of pancreas//malignant neoplasm of body of pancreas//malignant neoplasm of head of pancreas//malignant neoplasm of tail of pancreas//pancreas neoplasm//pancreatic neoplasm//pancreatic tumorPancreatic Neoplasms//Neoplasm, Pancreatic//Pancreatic Neoplasm//Pancreas Neoplasms//Neoplasm, Pancreas//Neoplasms, Pancreas//Pancreas Neoplasm//Neoplasms, Pancreatic//Cancer of Pancreas//Pancreas Cancers//Pancreas Cancer//Cancer, Pancreas//Cancers, Pancreas//Pancreatic Cancer//Cancer, Pancreatic//Cancers, Pancreatic//Pancreatic Cancers//Cancer of the Pancreas

 

Disease Association Statistics

Total Associated ncRNA Number:322   
More Information
Causal ncRNA Number:280
Network:
Top Causal ncRNAs:
DANCR  (Score: 1)
XIST  (Score: 1)
LINC00261  (Score: 1)
DANCR  (Score: 1)
XIST  (Score: 1)
LINC00261  (Score: 1)
CASC2  (Score: 0.999893)
CASC2  (Score: 0.999893)
LINC00460  (Score: 0.999893)
LINC00460  (Score: 0.999893)
More Information

 

Evidence Support

Strong Evidence:qRT-PCR
Weak Evidence:

 

Reference

[1] PubMed ID:32770626
Disease Name:Pancreatic Neoplasms
Sample:PC tissues and cell lines
Dysfunction Pattern:regulation[SYNCRIP ]
Validated Method:qRT-PCR
Description:Our results showed that lncNT5E was significantly up-regulated in PC tissues and cell lines and associated with poor prognosis. In conclusion, lncNT5E predicts poor prognosis and promotes PC progression by modulating SYNCRIP expression.
Causality:Yes
Causal Description: LncNT5E depletion inhibited PC cell proliferation, migration, invasion and EMT in vitro and caused tumorigenesis arrest in vivo.
Clinical-realted Application:Our results showed that lncNT5E was significantly up-regulated in PC tissues and cell lines and associated with poor prognosis.