Entry Detail

General Information

Database ID: LDA0007746
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:NEAT1
Full Name:nuclear paraspeckle assembly transcript 1
Category:LncRNA
Species:Homo sapiens
Synonyms:LINC00084|NCRNA00084|TP53LC15|TncRNA|VINC
Chromosome:11
Strand:+
Coordinate:
Start Site(bp):65422798End Site(bp):65445540
External Links:
Ensembl ID:ENSG00000245532
Ensembl Transcript ID:N/A
Entrez Gene:283131.0
NONCODE ID:N/A
RefSeq Accession:NR_131012.1

 

ncRNA Association Statistics

Total Associated Disease Number:190   
More Information
Causal Disease Number:146
Network:
Top Causal Diseases:
Parkinson Disease  (Score: 1)
Ovarian Neoplasms  (Score: 1)
Non-alcoholic Fatty Liver Disease  (Score: 1)
Parkinson Disease  (Score: 1)
Leukemia, Myeloid, Acute  (Score: 1)
Osteosarcoma  (Score: 1)
Osteosarcoma  (Score: 1)
Leukemia, Myeloid, Acute  (Score: 1)
Colorectal Neoplasms  (Score: 1)
Carcinoma, Hepatocellular  (Score: 1)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:5603
Disease Name:T-cell acute lymphoblastic leukemia
Category:Disease Ontology
Type:Hemic and Lymphatic Diseases
Define:An acute lymphoblastic leukemia that is characterized by too many T-cell lymphoblasts found in the bone marrow and blood.
Alias:Precursor T Lymphoblastic Leukemia//T Acute Lymphoblastic Leukemia//T-cell acute lymphocytic leukaemia

 

Disease Association Statistics

Total Associated ncRNA Number:10   
More Information
Causal ncRNA Number:10
Network:
Top Causal ncRNAs:
CDKN2B-AS1  (Score: 0.731059)
EBLN3P  (Score: 0.731059)
PPM1A-AS  (Score: 0.731059)
circPRKDC  (Score: 0.731059)
NEAT1  (Score: 0.731059)
CDKN2B-AS1  (Score: 0.731059)
EBLN3P  (Score: 0.731059)
PPM1A-AS  (Score: 0.731059)
circPRKDC  (Score: 0.731059)
NEAT1  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:Western Blot//qRT-PCR//MTT//Luciferase Report Assay//Colony Formation Assay
Weak Evidence:

 

Reference

[1] PubMed ID:33010698
Disease Name:T-cell acute lymphoblastic leukemia
Sample:T-ALL cells
Dysfunction Pattern:regulation[miR-146b-5p/NOTCH1 signaling pathway]
Validated Method:Western Blot//qRT-PCR//MTT//Luciferase Report Assay//Colony Formation Assay
Description:The expression levels of NEAT1 were markedly increased, but miR-146b-5p levels were reduced in T-ALL cells. NEAT1 promotes the proliferation of T-ALL cells by sponging miR-146b-5p to upregulate the expression of NOTCH1.
Causality:Yes
Causal Description:Knockdown of NEAT1 or overexpression of miR-146b-5p decreased NOTCH1 expression, inhibited the proliferation of T-ALL cells.
Clinical-realted Application: