Entry Detail

General Information

Database ID: LDA0007747
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:MEG3
Full Name:maternally expressed 3
Category:LncRNA
Species:Homo sapiens
Synonyms:FP504|GTL2|LINC00023|NCRNA00023|PRO0518|PRO2160|onco-lncRNA-83|prebp1
Chromosome:14
Strand:+
Coordinate:
Start Site(bp):100826108End Site(bp):100861026
External Links:
Ensembl ID:ENSG00000214548
Ensembl Transcript ID:ENSG00000214548
Entrez Gene:55384.0
NONCODE ID:N/A
RefSeq Accession:NR_003531.3

 

ncRNA Association Statistics

Total Associated Disease Number:114   
More Information
Causal Disease Number:78
Network:
Top Causal Diseases:
Stomach Neoplasms  (Score: 1)
Carcinoma, Non-Small-Cell Lung  (Score: 1)
Carcinoma, Hepatocellular  (Score: 1)
Sepsis  (Score: 1)
Glioma  (Score: 1)
Breast Neoplasms  (Score: 1)
Carcinoma, Non-Small-Cell Lung  (Score: 1)
Sepsis  (Score: 1)
Carcinoma, Hepatocellular  (Score: 1)
Breast Neoplasms  (Score: 1)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:D007414
Disease Name:Intestinal Neoplasms
Category:MeSH
Type:Neoplasms
Define:Tumors or cancer of the INTESTINES.
Alias:Intestinal Neoplasms//Intestinal Neoplasm//Neoplasm, Intestinal//Neoplasms, Intestinal//Intestines Neoplasms//Intestines Neoplasm//Neoplasm, Intestines//Neoplasms, Intestines//Cancer of Intestines//Intestines Cancers//Cancer of the Intestines//Intestines Cancer//Cancer, Intestines//Cancers, Intestines//Intestinal Cancer//Cancer, Intestinal//Cancers, Intestinal//Intestinal Cancers

 

Disease Association Statistics

Total Associated ncRNA Number:2   
More Information
Causal ncRNA Number:2
Network:
Top Causal ncRNAs:
MEG3  (Score: 0.731059)
MEG3  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:In Vivo Experiment//RNA Pull-Down//Western Blot//Flow Cytometry//qRT-PCR//FISH//RIP//Luciferase Report Assay//H&E Staining//Cell Proliferation Assay//IHC//IF
Weak Evidence:

 

Reference

[1] PubMed ID:34934045
Disease Name:Intestinal Neoplasms
Sample:clinical samples and in the Apcmin mouse model
Dysfunction Pattern:Regulation(miR-708/SOCS3/STAT3 signaling)
Validated Method:In Vivo Experiment//RNA Pull-Down//Western Blot//Flow Cytometry//qRT-PCR//FISH//RIP//Luciferase Report Assay//H&E Staining//Cell Proliferation Assay//IHC//Bioinformatics Analysis//IF
Description:Our data showed Meg3 levels negatively correlate with miR-708 levels both in clinical samples and in the Apcmin mouse model, which indicated that Meg3 acts as a competitive endogenous RNA (ceRNA) of miR-708. Then, miR-708 served as an oncogene, inducing neoplasia in both Apcmin mice and cultured colonic organoids. Put together, miR-708 appears to promote malignant proliferation of colonic stem cells by targeting SOCS3/STAT3 signaling.
Causality:Yes
Causal Description:Then, miR-708 served as an oncogene, inducing neoplasia in both Apcmin mice and cultured colonic organoids. Put together, miR-708 appears to promote malignant proliferation of colonic stem cells by targeting SOCS3/STAT3 signaling.
Clinical-realted Application: