Entry Detail

General Information

Database ID: LDA0007748
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:MEG3
Full Name:maternally expressed 3
Category:LncRNA
Species:Homo sapiens
Synonyms:FP504|GTL2|LINC00023|NCRNA00023|PRO0518|PRO2160|onco-lncRNA-83|prebp1
Chromosome:14
Strand:+
Coordinate:
Start Site(bp):100826108End Site(bp):100861026
External Links:
Ensembl ID:ENSG00000214548
Ensembl Transcript ID:ENSG00000214548
Entrez Gene:55384.0
NONCODE ID:N/A
RefSeq Accession:NR_003531.3

 

ncRNA Association Statistics

Total Associated Disease Number:114   
More Information
Causal Disease Number:78
Network:
Top Causal Diseases:
Stomach Neoplasms  (Score: 1)
Carcinoma, Non-Small-Cell Lung  (Score: 1)
Carcinoma, Hepatocellular  (Score: 1)
Sepsis  (Score: 1)
Glioma  (Score: 1)
Breast Neoplasms  (Score: 1)
Carcinoma, Non-Small-Cell Lung  (Score: 1)
Sepsis  (Score: 1)
Carcinoma, Hepatocellular  (Score: 1)
Breast Neoplasms  (Score: 1)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:D013119
Disease Name:Spinal Cord Injuries
Category:MeSH
Type:Nervous System Diseases
Define:Penetrating and non-penetrating injuries to the spinal cord resulting from traumatic external forces (e.g., WOUNDS, GUNSHOT; WHIPLASH INJURIES; etc.).
Alias:Spinal Cord Injuries//Spinal Cord Trauma//Cord Trauma, Spinal//Cord Traumas, Spinal//Spinal Cord Traumas//Trauma, Spinal Cord//Traumas, Spinal Cord//Myelopathy, Traumatic//Myelopathies, Traumatic//Traumatic Myelopathies//Traumatic Myelopathy//Injuries, Spinal Cord//Cord Injuries, Spinal//Cord Injury, Spinal//Injury, Spinal Cord//Spinal Cord Injury//Spinal Cord Transection//Cord Transection, Spinal//Cord Transections, Spinal//Spinal Cord Transections//Transection, Spinal Cord//Transections, Spinal Cord//Spinal Cord Laceration//Cord Laceration, Spinal//Cord Lacerations, Spinal//Laceration, Spinal Cord//Lacerations, Spinal Cord//Spinal Cord Lacerations//Post-Traumatic Myelopathy//Myelopathies, Post-Traumatic//Myelopathy, Post-Traumatic//Post Traumatic Myelopathy//Post-Traumatic Myelopathies//Spinal Cord Contusion//Contusion, Spinal Cord//Contusions, Spinal Cord//Cord Contusion, Spinal//Cord Contusions, Spinal//Spinal Cord Contusions

 

Disease Association Statistics

Total Associated ncRNA Number:36   
More Information
Causal ncRNA Number:36
Network:
Top Causal ncRNAs:
Vof-16  (Score: 0.731059)
HECW1  (Score: 0.731059)
Hipk3  (Score: 0.731059)
LEF1-AS1  (Score: 0.731059)
LINC00158  (Score: 0.731059)
Irag2-208  (Score: 0.731059)
LncRNAAirsci  (Score: 0.731059)
CASC9  (Score: 0.731059)
PRKCSH  (Score: 0.731059)
MEG3  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:In Vivo Experiment//RNA Pull-Down//Western Blot//Transfection//CCK8//qRT-PCR//RIP//IF//ELISA//Transwell Assay
Weak Evidence:

 

Reference

[1] PubMed ID:35338543
Disease Name:Spinal Cord Injuries
Sample: ASCI mouse spinal cord tissues, primary microglia and BV2 cells
Dysfunction Pattern:Interaction(HuR/A20/NF-κB axis)
Validated Method:In Vivo Experiment//RNA Pull-Down//Western Blot//Transfection//CCK8//qRT-PCR//RIP//ELISA//Transwell Assay//IF
Description:The lncRNA MEG3 expression was lessened in the ASCI mouse spinal cord tissues and LPS-treated primary microglia and BV2 cells, and the overexpression of lncRNA MEG3 restrained the M1 polarization of microglia and the neuroinflammation by regulating the NF-κB signaling pathway. For the investigation of the potential mechanism of such, the overexpression of lncRNA MEG3 restrained the M1 polarization of microglia through the HuR/A20/NF-κB axis and boosted the motor function recovery and neuroinflammation relief in the mice with SCI. The overexpression of lncRNA MEG3 restrained the M1 polarization of microglia through the HuR/A20/NF-κB axis.
Causality:Yes
Causal Description: For the investigation of the potential mechanism of such, the overexpression of lncRNA MEG3 restrained the M1 polarization of microglia through the HuR/A20/NF-κB axis and boosted the motor function recovery and neuroinflammation relief in the mice with SCI. The overexpression of lncRNA MEG3 restrained the M1 polarization of microglia through the HuR/A20/NF-κB axis.
Clinical-realted Application: