Entry Detail

General Information

Database ID: LDA0007751
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:NEAT1
Full Name:nuclear paraspeckle assembly transcript 1
Category:LncRNA
Species:Homo sapiens
Synonyms:LINC00084|NCRNA00084|TP53LC15|TncRNA|VINC
Chromosome:11
Strand:+
Coordinate:
Start Site(bp):65422798End Site(bp):65445540
External Links:
Ensembl ID:ENSG00000245532
Ensembl Transcript ID:N/A
Entrez Gene:283131.0
NONCODE ID:N/A
RefSeq Accession:NR_131012.1

 

ncRNA Association Statistics

Total Associated Disease Number:190   
More Information
Causal Disease Number:146
Network:
Top Causal Diseases:
Parkinson Disease  (Score: 1)
Ovarian Neoplasms  (Score: 1)
Non-alcoholic Fatty Liver Disease  (Score: 1)
Parkinson Disease  (Score: 1)
Leukemia, Myeloid, Acute  (Score: 1)
Osteosarcoma  (Score: 1)
Osteosarcoma  (Score: 1)
Leukemia, Myeloid, Acute  (Score: 1)
Colorectal Neoplasms  (Score: 1)
Carcinoma, Hepatocellular  (Score: 1)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:13328
Disease Name:diabetic cataract
Category:Disease Ontology
Type:Endocrine System Diseases
Define:A cataract that is characterized by loss of lens transparency secondary to hyperglycemia related to diabetes mellitus.
Alias:Cataract - diabetic

 

Disease Association Statistics

Total Associated ncRNA Number:2   
More Information
Causal ncRNA Number:2
Network:
Top Causal ncRNAs:
NEAT1  (Score: 0.731059)
NEAT1  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:qRT-PCR//Luciferase Report Assay//ChIP
Weak Evidence:

 

Reference

[1] PubMed ID:32572898
Disease Name:diabetic cataract
Sample:anterior capsule tissue
Dysfunction Pattern:regulation[microRNA-205-3p/MMP16 axis]
Validated Method:qRT-PCR//Luciferase Report Assay//ChIP
Description:YY1 and NEAT1 expressions in the anterior capsule tissue of DC lens were remarkably reduced and positively correlated. The low expression of YY1 induces NEAT1 downregulation, which regulates microRNA-205-3p/MMP16 axis and thus participates in the development of DC.
Causality:Yes
Causal Description:Knockdown of NEAT1 inhibited proliferation while promoted apoptosis under high glucose conditions.
Clinical-realted Application: