Entry Detail

General Information

Database ID: LDA0007759
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:NEAT1
Full Name:nuclear paraspeckle assembly transcript 1
Category:LncRNA
Species:Homo sapiens
Synonyms:LINC00084|NCRNA00084|TP53LC15|TncRNA|VINC
Chromosome:11
Strand:+
Coordinate:
Start Site(bp):65422798End Site(bp):65445540
External Links:
Ensembl ID:ENSG00000245532
Ensembl Transcript ID:N/A
Entrez Gene:283131.0
NONCODE ID:N/A
RefSeq Accession:NR_131012.1

 

ncRNA Association Statistics

Total Associated Disease Number:190   
More Information
Causal Disease Number:146
Network:
Top Causal Diseases:
Parkinson Disease  (Score: 1)
Ovarian Neoplasms  (Score: 1)
Non-alcoholic Fatty Liver Disease  (Score: 1)
Parkinson Disease  (Score: 1)
Leukemia, Myeloid, Acute  (Score: 1)
Osteosarcoma  (Score: 1)
Osteosarcoma  (Score: 1)
Leukemia, Myeloid, Acute  (Score: 1)
Colorectal Neoplasms  (Score: 1)
Carcinoma, Hepatocellular  (Score: 1)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:D007627
Disease Name:Keloid
Category:MeSH
Type:Tissues
Define:A sharply elevated, irregularly shaped, progressively enlarging scar resulting from formation of excessive amounts of collagen in the dermis during connective tissue repair. It is differentiated from a hypertrophic scar (CICATRIX, HYPERTROPHIC) in that the former does not spread to surrounding tissues.
Alias:Keloid//Keloids

 

Disease Association Statistics

Total Associated ncRNA Number:14   
More Information
Causal ncRNA Number:14
Network:
Top Causal ncRNAs:
HOXA11-AS  (Score: 0.985791)
H19  (Score: 0.985791)
HOXA11-AS  (Score: 0.985791)
H19  (Score: 0.985791)
GNAS-AS1  (Score: 0.731059)
CACNA1G-AS1  (Score: 0.731059)
hsa_circ_0043688  (Score: 0.731059)
circNRIP1  (Score: 0.731059)
NEAT1  (Score: 0.731059)
GNAS-AS1  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:Western Blot//Transfection//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay
Weak Evidence:

 

Reference

[1] PubMed ID:33162101
Disease Name:Keloid
Sample:keloid tissues and fibroblasts
Dysfunction Pattern:Interaction(miR-196b-5p/FGF2 Axis)
Validated Method:Western Blot//Transfection//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay
Description:NEAT1 was increased and miR-196b-5p was decreased in keloid tissues and fibroblasts. NEAT1 knockdown or miR-196b-5p overexpression suppressed cell viability, migration, and extracellular matrix (ECM) component production in keloid fibroblasts. MiR-196 b-5p was a target of NEAT1, and NEAT1 overexpression reversed the effect of miR-196b-5p on keloid fibroblast progression. Moreover, we found that miR-196b-5p directly targeted FGF2. FGF2 knockdown suppressed keloid fibroblast viability, migration, and ECM protein production. FGF2 overexpression abolished the effect of miR-196b-5p overexpression on keloid fibroblast development.
Causality:Yes
Causal Description:NEAT1 knockdown or miR-196b-5p overexpression suppressed cell viability, migration, and extracellular matrix (ECM) component production in keloid fibroblasts.
Clinical-realted Application: