Entry Detail

General Information

Database ID: LDA0007778
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:NEAT1
Full Name:nuclear paraspeckle assembly transcript 1
Category:LncRNA
Species:Homo sapiens
Synonyms:LINC00084|NCRNA00084|TP53LC15|TncRNA|VINC
Chromosome:11
Strand:+
Coordinate:
Start Site(bp):65422798End Site(bp):65445540
External Links:
Ensembl ID:ENSG00000245532
Ensembl Transcript ID:N/A
Entrez Gene:283131.0
NONCODE ID:N/A
RefSeq Accession:NR_131012.1

 

ncRNA Association Statistics

Total Associated Disease Number:190   
More Information
Causal Disease Number:146
Network:
Top Causal Diseases:
Parkinson Disease  (Score: 1)
Ovarian Neoplasms  (Score: 1)
Non-alcoholic Fatty Liver Disease  (Score: 1)
Parkinson Disease  (Score: 1)
Leukemia, Myeloid, Acute  (Score: 1)
Osteosarcoma  (Score: 1)
Osteosarcoma  (Score: 1)
Leukemia, Myeloid, Acute  (Score: 1)
Colorectal Neoplasms  (Score: 1)
Carcinoma, Hepatocellular  (Score: 1)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:14004D017545
Disease Name:thoracic aortic aneurysmAortic Aneurysm, Thoracic
Category:Disease OntologyMeSH
Type:Cardiovascular Diseases
Define:An aortic aneurysm that is located_in the thoracic aorta.An abnormal balloon- or sac-like dilatation in the wall of the THORACIC AORTA. This proximal descending portion of aorta gives rise to the visceral and the parietal branches above the aortic hiatus at the diaphragm.
Alias:Aortic Aneurysm, Thoracic//Thoracic Aortic Aneurysms//Thoracic Aorta Aneurysm//Aneurysm, Thoracic Aortic//Aneurysm, Thoracic Aorta//Aorta Aneurysm, Thoracic//Thoracic Aorta Aneurysms//Thoracic Aortic Aneurysm

 

Disease Association Statistics

Total Associated ncRNA Number:16   
More Information
Causal ncRNA Number:6
Network:
Top Causal ncRNAs:
HOXA-AS2  (Score: 0.731059)
H19  (Score: 0.731059)
NEAT1  (Score: 0.731059)
HOXA-AS2  (Score: 0.731059)
H19  (Score: 0.731059)
NEAT1  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:RNA Pull-Down//Western Blot//Transfection//Tunel//CCK8//qRT-PCR//Flow Cytometry//FISH//RIP//Luciferase Report Assay//EdU Staining
Weak Evidence:

 

Reference

[1] PubMed ID:34373133
Disease Name:Aortic Aneurysm, Thoracic
Sample:HAoSMC and HA-VSMC cells.
Dysfunction Pattern:Interaction(miR-324-5p/RAN)
Validated Method:RNA Pull-Down//Western Blot//Transfection//Tunel//CCK8//qRT-PCR//Flow Cytometry//FISH//RIP//Luciferase Report Assay//EdU Staining
Description:NEAT1 was up-regulated in TAA patients, as well as HAoSMC and HA-VSMC cells. Down-regulation of NEAT1 could inhibit the proliferative abilities while promoting apoptosis of TAA cells. MiR-324-5p expression was down-regulated in both TAA tissues and cells. Then, RAN was selected out as a target of miR-324-5p. More interestingly, miR-324-5p had inhibitory effects on malignant behaviors of TAA cells. RAN was negatively related with miR-324-5p while positively correlated with NEAT1 in the tissues. Finally, the data of rescue assays manifested that RAN up-regulation could countervail the influence of down-regulation of NEAT1 on TAA cells.
Causality:Yes
Causal Description:Finally, the data of rescue assays manifested that RAN up-regulation could countervail the influence of down-regulation of NEAT1 on TAA cells.
Clinical-realted Application: