Entry Detail

General Information

Database ID: LDA0007783
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:NORAD
Full Name:non-coding RNA activated by DNA damage
Category:LncRNA
Species:Homo sapiens
Synonyms:LINC00657
Chromosome:20
Strand:-
Coordinate:
Start Site(bp):36045618End Site(bp):36050960
External Links:
Ensembl ID:ENSG00000260032
Ensembl Transcript ID:N/A
Entrez Gene:647979.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:50   
More Information
Causal Disease Number:38
Network:
Top Causal Diseases:
Stomach Neoplasms  (Score: 1)
Prostatic Neoplasms  (Score: 1)
Squamous Cell Carcinoma of Head and Neck  (Score: 1)
Carcinoma, Hepatocellular  (Score: 1)
Carcinoma, Non-Small-Cell Lung  (Score: 1)
Stomach Neoplasms  (Score: 1)
Breast Neoplasms  (Score: 1)
Prostatic Neoplasms  (Score: 1)
Breast Neoplasms  (Score: 1)
Carcinoma, Hepatocellular  (Score: 1)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:D010020
Disease Name:Osteonecrosis
Category:MeSH
Type:Musculoskeletal Diseases
Define:Death of a bone or part of a bone, either atraumatic or posttraumatic.
Alias:Osteonecrosis//Osteonecroses//Bone Necrosis//Bone Necroses//Necroses, Bone//Necrosis, Bone//Necrosis, Avascular, of Bone//Avascular Necrosis of Bone//Bone Avascular Necrosis//Kienbock Disease//Kienbock's Disease//Kienboeck Disease//Kienboeck's Disease//Kienboecks Disease//Necrosis, Aseptic, of Bone//Aseptic Necrosis of Bone//Bone Aseptic Necrosis

 

Disease Association Statistics

Total Associated ncRNA Number:6   
More Information
Causal ncRNA Number:4
Network:
Top Causal ncRNAs:
FGD5-AS1  (Score: 0.731059)
NORAD  (Score: 0.731059)
FGD5-AS1  (Score: 0.731059)
NORAD  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:Western Blot//Transfection//qRT-PCR//Luciferase Report Assay//Cell Apoptosis Assay//Cell Proliferation Assay
Weak Evidence:

 

Reference

[1] PubMed ID:33413642
Disease Name:Osteonecrosis
Sample:SONFH tissues
Dysfunction Pattern:Interaction(miR-26a-5p)
Validated Method:Western Blot//Transfection//qRT-PCR//Luciferase Report Assay//Cell Apoptosis Assay//Cell Proliferation Assay
Description: NORAD expression was downregulated in SONFH tissues, while miR-26a-5p expression was upregulated. Moreover, NORAD improved DEX-induced inhibition of proliferation and differentiation, and promotion of apoptosis by regulation of miR-26a-5p in hBMSCs.
Causality:Yes
Causal Description:Overexpression of NORAD improved DEX-induced inhibition of proliferation and differentiation, and promotion of apoptosis in hBMSCs, while knockdown of NORAD led to the opposite results.
Clinical-realted Application: