Entry Detail

General Information

Database ID: LDA0007787
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:NORAD
Full Name:non-coding RNA activated by DNA damage
Category:LncRNA
Species:Homo sapiens
Synonyms:LINC00657
Chromosome:20
Strand:-
Coordinate:
Start Site(bp):36045618End Site(bp):36050960
External Links:
Ensembl ID:ENSG00000260032
Ensembl Transcript ID:N/A
Entrez Gene:647979.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:50   
More Information
Causal Disease Number:38
Network:
Top Causal Diseases:
Stomach Neoplasms  (Score: 1)
Prostatic Neoplasms  (Score: 1)
Squamous Cell Carcinoma of Head and Neck  (Score: 1)
Carcinoma, Hepatocellular  (Score: 1)
Carcinoma, Non-Small-Cell Lung  (Score: 1)
Stomach Neoplasms  (Score: 1)
Breast Neoplasms  (Score: 1)
Prostatic Neoplasms  (Score: 1)
Breast Neoplasms  (Score: 1)
Carcinoma, Hepatocellular  (Score: 1)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:8893D011565
Disease Name:psoriasisPsoriasis
Category:Disease OntologyMeSH
Type:Skin and Connective Tissue Diseases
Define:A skin disease that is characterized by patches of thick red skin and silvery scales.A common genetically determined, chronic, inflammatory skin disease characterized by rounded erythematous, dry, scaling patches. The lesions have a predilection for nails, scalp, genitalia, extensor surfaces, and the lumbosacral region. Accelerated epidermopoiesis is considered to be the fundamental pathologic feature in psoriasis.
Alias:Psoriasis//Psoriases//Pustulosis of Palms and Soles//Pustulosis Palmaris et Plantaris//Palmoplantaris Pustulosis//Pustular Psoriasis of Palms and Soles

 

Disease Association Statistics

Total Associated ncRNA Number:28   
More Information
Causal ncRNA Number:18
Network:
Top Causal ncRNAs:
HOTAIR  (Score: 0.731059)
NORAD  (Score: 0.731059)
Meg3  (Score: 0.731059)
SPRR2C  (Score: 0.731059)
circVAPA  (Score: 0.731059)
circEIF5  (Score: 0.731059)
XIST  (Score: 0.731059)
AGAP2-AS1  (Score: 0.731059)
chr2:206992521|206994966  (Score: 0.731059)
HOTAIR  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:In Vivo Experiment//RNA Pull-Down//Western Blot//Transfection//qRT-PCR//FISH//RIP//MTT//Luciferase Report Assay//Cell Proliferation Assay
Weak Evidence:

 

Reference

[1] PubMed ID:33759666
Disease Name:Psoriasis
Sample:HaCaT cells
Dysfunction Pattern:Interaction(miR-26a)
Validated Method:In Vivo Experiment//RNA Pull-Down//Western Blot//Transfection//qRT-PCR//FISH//RIP//MTT//Luciferase Report Assay//Cell Proliferation Assay
Description: In IL-22/LPS-stimulated HaCaT cells, NORAD, CDC6, and keratinocyte proliferation-related proteins (K6, K16, and K17) were up-regulated and miR-26a was down-regulated. Cell survival and proliferation were also increased. However, the results were reversed after interference with NORAD.Also, in vitro experiments revealed that NORAD negatively regulated miR-26a.
Causality:Yes
Causal Description: In IL-22/LPS-stimulated HaCaT cells, NORAD, CDC6, and keratinocyte proliferation-related proteins (K6, K16, and K17) were up-regulated and miR-26a was down-regulated. Cell survival and proliferation were also increased. However, the results were reversed after interference with NORAD.
Clinical-realted Application: