Entry Detail

General Information

Database ID: LDA0007792
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:NEAT1
Full Name:nuclear paraspeckle assembly transcript 1
Category:LncRNA
Species:Homo sapiens
Synonyms:LINC00084|NCRNA00084|TP53LC15|TncRNA|VINC
Chromosome:11
Strand:+
Coordinate:
Start Site(bp):65422798End Site(bp):65445540
External Links:
Ensembl ID:ENSG00000245532
Ensembl Transcript ID:N/A
Entrez Gene:283131.0
NONCODE ID:N/A
RefSeq Accession:NR_131012.1

 

ncRNA Association Statistics

Total Associated Disease Number:190   
More Information
Causal Disease Number:146
Network:
Top Causal Diseases:
Parkinson Disease  (Score: 1)
Ovarian Neoplasms  (Score: 1)
Non-alcoholic Fatty Liver Disease  (Score: 1)
Parkinson Disease  (Score: 1)
Leukemia, Myeloid, Acute  (Score: 1)
Osteosarcoma  (Score: 1)
Osteosarcoma  (Score: 1)
Leukemia, Myeloid, Acute  (Score: 1)
Colorectal Neoplasms  (Score: 1)
Carcinoma, Hepatocellular  (Score: 1)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:D013119
Disease Name:Spinal Cord Injuries
Category:MeSH
Type:Nervous System Diseases
Define:Penetrating and non-penetrating injuries to the spinal cord resulting from traumatic external forces (e.g., WOUNDS, GUNSHOT; WHIPLASH INJURIES; etc.).
Alias:Spinal Cord Injuries//Spinal Cord Trauma//Cord Trauma, Spinal//Cord Traumas, Spinal//Spinal Cord Traumas//Trauma, Spinal Cord//Traumas, Spinal Cord//Myelopathy, Traumatic//Myelopathies, Traumatic//Traumatic Myelopathies//Traumatic Myelopathy//Injuries, Spinal Cord//Cord Injuries, Spinal//Cord Injury, Spinal//Injury, Spinal Cord//Spinal Cord Injury//Spinal Cord Transection//Cord Transection, Spinal//Cord Transections, Spinal//Spinal Cord Transections//Transection, Spinal Cord//Transections, Spinal Cord//Spinal Cord Laceration//Cord Laceration, Spinal//Cord Lacerations, Spinal//Laceration, Spinal Cord//Lacerations, Spinal Cord//Spinal Cord Lacerations//Post-Traumatic Myelopathy//Myelopathies, Post-Traumatic//Myelopathy, Post-Traumatic//Post Traumatic Myelopathy//Post-Traumatic Myelopathies//Spinal Cord Contusion//Contusion, Spinal Cord//Contusions, Spinal Cord//Cord Contusion, Spinal//Cord Contusions, Spinal//Spinal Cord Contusions

 

Disease Association Statistics

Total Associated ncRNA Number:36   
More Information
Causal ncRNA Number:36
Network:
Top Causal ncRNAs:
Vof-16  (Score: 0.731059)
HECW1  (Score: 0.731059)
Hipk3  (Score: 0.731059)
LEF1-AS1  (Score: 0.731059)
LINC00158  (Score: 0.731059)
Irag2-208  (Score: 0.731059)
LncRNAAirsci  (Score: 0.731059)
CASC9  (Score: 0.731059)
PRKCSH  (Score: 0.731059)
MEG3  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:RNA Pull-Down//Western Blot//Transfection//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay
Weak Evidence:

 

Reference

[1] PubMed ID:34151707
Disease Name:Spinal Cord Injuries
Sample:PC-12 cells
Dysfunction Pattern:Interaction(miR-211-5p/MAPK1 axis)
Validated Method:RNA Pull-Down//Western Blot//Transfection//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay
Description: It was found that LPS induced inflammation in the PC-12 cells, leading to significantly higher cell apoptosis rate and lower viability, and the expression level of NEAT1 was elevated by LPS. Taken together, the knockdown of NEAT1 remarkably alleviated the inflammation of SCI via miR-211-5p/MAPK1 axis.
Causality:Yes
Causal Description:However, knockdown of NEAT1 partially reversed the effects of LPS. Subsequently, the potential interaction between NEAT1 and miR-211-5p was validated and miR-211-5p inhibitor was further confirmed to antagonize the effects of NEAT knockdown.
Clinical-realted Application: