Entry Detail

General Information

Database ID: LDA0007797
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:NORAD
Full Name:non-coding RNA activated by DNA damage
Category:LncRNA
Species:Homo sapiens
Synonyms:LINC00657
Chromosome:20
Strand:-
Coordinate:
Start Site(bp):36045618End Site(bp):36050960
External Links:
Ensembl ID:ENSG00000260032
Ensembl Transcript ID:N/A
Entrez Gene:647979.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:50   
More Information
Causal Disease Number:38
Network:
Top Causal Diseases:
Stomach Neoplasms  (Score: 1)
Prostatic Neoplasms  (Score: 1)
Squamous Cell Carcinoma of Head and Neck  (Score: 1)
Carcinoma, Hepatocellular  (Score: 1)
Carcinoma, Non-Small-Cell Lung  (Score: 1)
Stomach Neoplasms  (Score: 1)
Breast Neoplasms  (Score: 1)
Prostatic Neoplasms  (Score: 1)
Breast Neoplasms  (Score: 1)
Carcinoma, Hepatocellular  (Score: 1)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:8577D003093
Disease Name:ulcerative colitisColitis, Ulcerative
Category:Disease OntologyMeSH
Type:Digestive System Diseases
Define:A colitis that is predominantly confined to the mucosa located_in colon and includes characteristic ulcers, or open sores.Inflammation of the COLON that is predominantly confined to the MUCOSA. Its major symptoms include DIARRHEA, rectal BLEEDING, the passage of MUCUS, and ABDOMINAL PAIN.
Alias:Left-sided ulcerative colitisColitis, Ulcerative//Idiopathic Proctocolitis//Ulcerative Colitis//Colitis Gravis//Inflammatory Bowel Disease, Ulcerative Colitis Type

 

Disease Association Statistics

Total Associated ncRNA Number:16   
More Information
Causal ncRNA Number:14
Network:
Top Causal ncRNAs:
H19  (Score: 0.985791)
H19  (Score: 0.985791)
hsa_circ_0001187  (Score: 0.731059)
Tug1  (Score: 0.731059)
SNHG5  (Score: 0.731059)
NORAD  (Score: 0.731059)
Meg3  (Score: 0.731059)
MEG3  (Score: 0.731059)
hsa_circ_0001187  (Score: 0.731059)
Tug1  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:Western Blot//Transfection//Flow Cytometry//qRT-PCR//RIP//MTT//Luciferase Report Assay//ELISA//EdU Staining
Weak Evidence:

 

Reference

[1] PubMed ID:35412486
Disease Name:Colitis, Ulcerative
Sample: UC patient-derived colonic mucosal tissues, FHCs
Dysfunction Pattern:Interaction( miR-552-3p/MYD88 axis)
Validated Method:Western Blot//Transfection//Flow Cytometry//qRT-PCR//RIP//MTT//Luciferase Report Assay//ELISA//EdU Staining
Description: Our data exhibited higher levels of NORAD in UC patient-derived colonic mucosal tissues and TNF-α-stimulated FHCs.NORAD acted as a miR-552-3p sponge, and miR-552-3p silencing weakened NORAD inhibition-mediated effects on TNF-α-induced FHC apoptosis, inflammation, and oxidative stress. Myeloid differentiation primary response gene 88 (MYD88) was verified as a miR-552-3p target, and MYD88 overexpression whittled miR-552-3p mimic-mediated inhibition on TNF-α-induced FHC apoptosis, inflammation, and oxidative stress. Notably, TNF-α-induced NORAD regulated the nuclear factor-κappaB (NF-κB) signaling via the miR-552-3p/MYD88 axis.
Causality:Yes
Causal Description:Functional experiments presented that NORAD inhibition impaired TNF-α-induced FHC apoptosis, inflammation, and oxidative stress.
Clinical-realted Application: