Entry Detail

General Information

Database ID: LDA0007824
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:MCM3AP-AS1
Full Name:MCM3AP antisense RNA 1
Category:LncRNA
Species:Homo sapiens
Synonyms:C21orf85|MCM3AP-AS|MCM3APAS|MCM3APASB|NCRNA00031
Chromosome:21
Strand:+
Coordinate:
Start Site(bp):46229231End Site(bp):46251701
External Links:
Ensembl ID:ENSG00000215424
Ensembl Transcript ID:N/A
Entrez Gene:114044.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:30   
More Information
Causal Disease Number:26
Network:
Top Causal Diseases:
Colorectal Neoplasms  (Score: 1)
Colorectal Neoplasms  (Score: 1)
Breast Neoplasms  (Score: 0.999893)
Breast Neoplasms  (Score: 0.999893)
cervical squamous cell carcinoma  (Score: 0.985791)
Thyroid Cancer, Papillary  (Score: 0.985791)
Squamous Cell Carcinoma of Head and Neck  (Score: 0.985791)
Osteoarthritis  (Score: 0.985791)
cervical squamous cell carcinoma  (Score: 0.985791)
Prostatic Neoplasms  (Score: 0.985791)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:255D006391
Disease Name:hemangiomaHemangioma
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A cardiovascular organ benign neoplasm that has_material_basis_in endothelial cells that line blood vessels and is characterised by increased number of normal or abnormal vessels filled with blood.A vascular anomaly due to proliferation of BLOOD VESSELS that forms a tumor-like mass. The common types involve CAPILLARIES and VEINS. It can occur anywhere in the body but is most frequently noticed in the SKIN and SUBCUTANEOUS TISSUE. (from Stedman, 27th ed, 2000)
Alias:Hemangioma//Hemangiomas//Hemangioma, Intramuscular//Hemangiomas, Intramuscular//Intramuscular Hemangioma//Intramuscular Hemangiomas//Hemangioma, Histiocytoid//Hemangiomas, Histiocytoid//Histiocytoid Hemangioma//Histiocytoid Hemangiomas//Angioma//Chorioangioma//Chorioangiomas//Chorangioma//Chorangiomas

 

Disease Association Statistics

Total Associated ncRNA Number:12   
More Information
Causal ncRNA Number:12
Network:
Top Causal ncRNAs:
circAP2A2  (Score: 0.731059)
NEAT1  (Score: 0.731059)
MEG3  (Score: 0.731059)
MEG8  (Score: 0.731059)
OIP5-AS1  (Score: 0.731059)
MCM3AP-AS1  (Score: 0.731059)
circAP2A2  (Score: 0.731059)
NEAT1  (Score: 0.731059)
MEG3  (Score: 0.731059)
MEG8  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:ISH//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//IHC
Weak Evidence:

 

Reference

[1] PubMed ID:34660700
Disease Name:Hemangioma
Sample:IH patients
Dysfunction Pattern:Interaction( miR-138-5p/HIF-1α Axis-Regulated Glycolysis)
Validated Method:ISH//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//IHC
Description:We first documented that the expression of LncRNA MCM3AP-AS1 was significantly upregulated in IH. Furthermore, we demonstrated that MCM3AP-AS1 bound to miR-106b-3p which promotes glycolysis in IH.Taken together, we demonstrate that LncRNA-MCM3AP-AS1 promotes the progression of infantile hemangiomas by increasing the glycolysis via regulating miR-138-5p/HIF-1α axis.
Causality:Yes
Causal Description:In addition, we found that inhibition of HIF-1α contributed to the transformation of glycolysis to normal aerobic oxidation, partially reversed the promoting effect on glycolysis by the up-regulation of LncRNA MCM3AP-AS1 in IH disease. More importantly, we demonstrated this phenomenon existed in IH patients.
Clinical-realted Application: