Entry Detail

General Information

Database ID: LDA0007894
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:NEAT1
Full Name:nuclear paraspeckle assembly transcript 1
Category:LncRNA
Species:Homo sapiens
Synonyms:LINC00084|NCRNA00084|TP53LC15|TncRNA|VINC
Chromosome:11
Strand:+
Coordinate:
Start Site(bp):65422798End Site(bp):65445540
External Links:
Ensembl ID:ENSG00000245532
Ensembl Transcript ID:N/A
Entrez Gene:283131.0
NONCODE ID:N/A
RefSeq Accession:NR_131012.1

 

ncRNA Association Statistics

Total Associated Disease Number:190   
More Information
Causal Disease Number:146
Network:
Top Causal Diseases:
Parkinson Disease  (Score: 1)
Ovarian Neoplasms  (Score: 1)
Non-alcoholic Fatty Liver Disease  (Score: 1)
Parkinson Disease  (Score: 1)
Leukemia, Myeloid, Acute  (Score: 1)
Osteosarcoma  (Score: 1)
Osteosarcoma  (Score: 1)
Leukemia, Myeloid, Acute  (Score: 1)
Colorectal Neoplasms  (Score: 1)
Carcinoma, Hepatocellular  (Score: 1)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:10071
Disease Name:larynx squamous papilloma
Category:Disease Ontology
Type:Urogenital Diseases
Define:A laryngeal benign neoplasm that is characterized by the presence of a connective tissue core covered by stratified squamous epithelium and that has_symptom hoarseness.
Alias:

 

Disease Association Statistics

Total Associated ncRNA Number:2   
More Information
Causal ncRNA Number:2
Network:
Top Causal ncRNAs:
NEAT1  (Score: 0.731059)
NEAT1  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:Western Blot//Transfection//RIP//qRT-PCR//Luciferase Report Assay//Cell Proliferation Assay
Weak Evidence:

 

Reference

[1] PubMed ID:35012431
Disease Name:larynx squamous papilloma
Sample:LP tissues and cells
Dysfunction Pattern:Interaction(miR-577 or miR-1224-5p/CCNT2 axis)
Validated Method:Western Blot//Transfection//RIP//qRT-PCR//Luciferase Report Assay//Cell Proliferation Assay
Description: Lnc-NEAT1 was highly expressed in LP, and enhanced LP cell proliferation, and it was inhibited by Lnc-NEAT1 depleting. Concerning the underlying mechanism, it was found that Lnc-NEAT1 could functionally sponge microRNA-577 (miR-577) and microRNA-1224-5p (miR-1224-5p) and up-regulate Cyclin T2 (CCNT2) in LP cells. Notably, CCNT2 knockdown blocked Lnc-NEAT1-induced LP cell proliferation, and rescued cell apoptosis, which was specifically indicated by restoration of Bax, Cleaved caspase 3 and Cleaved caspase 9. Lnc-NEAT1 played a carcinogenic role in LP through mediating miR-577 or miR-1224-5p/CCNT2 axis, which may provide promising insights for the treatment of LP.
Causality:Yes
Causal Description: Lnc-NEAT1 was highly expressed in LP, and enhanced LP cell proliferation, and it was inhibited by Lnc-NEAT1 depleting.
Clinical-realted Application: