Entry Detail

General Information

Database ID: LDA0007934
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:MEG3
Full Name:maternally expressed 3
Category:LncRNA
Species:Homo sapiens
Synonyms:FP504|GTL2|LINC00023|NCRNA00023|PRO0518|PRO2160|onco-lncRNA-83|prebp1
Chromosome:14
Strand:+
Coordinate:
Start Site(bp):100826108End Site(bp):100861026
External Links:
Ensembl ID:ENSG00000214548
Ensembl Transcript ID:ENSG00000214548
Entrez Gene:55384.0
NONCODE ID:N/A
RefSeq Accession:NR_003531.3

 

ncRNA Association Statistics

Total Associated Disease Number:114   
More Information
Causal Disease Number:78
Network:
Top Causal Diseases:
Stomach Neoplasms  (Score: 1)
Carcinoma, Non-Small-Cell Lung  (Score: 1)
Carcinoma, Hepatocellular  (Score: 1)
Sepsis  (Score: 1)
Glioma  (Score: 1)
Breast Neoplasms  (Score: 1)
Carcinoma, Non-Small-Cell Lung  (Score: 1)
Sepsis  (Score: 1)
Carcinoma, Hepatocellular  (Score: 1)
Breast Neoplasms  (Score: 1)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:8577D003093
Disease Name:ulcerative colitisColitis, Ulcerative
Category:Disease OntologyMeSH
Type:Digestive System Diseases
Define:A colitis that is predominantly confined to the mucosa located_in colon and includes characteristic ulcers, or open sores.Inflammation of the COLON that is predominantly confined to the MUCOSA. Its major symptoms include DIARRHEA, rectal BLEEDING, the passage of MUCUS, and ABDOMINAL PAIN.
Alias:Left-sided ulcerative colitisColitis, Ulcerative//Idiopathic Proctocolitis//Ulcerative Colitis//Colitis Gravis//Inflammatory Bowel Disease, Ulcerative Colitis Type

 

Disease Association Statistics

Total Associated ncRNA Number:16   
More Information
Causal ncRNA Number:14
Network:
Top Causal ncRNAs:
H19  (Score: 0.985791)
H19  (Score: 0.985791)
hsa_circ_0001187  (Score: 0.731059)
Tug1  (Score: 0.731059)
SNHG5  (Score: 0.731059)
NORAD  (Score: 0.731059)
Meg3  (Score: 0.731059)
MEG3  (Score: 0.731059)
hsa_circ_0001187  (Score: 0.731059)
Tug1  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:Western Blot//Tunel//CCK8//Flow Cytometry//FISH//RIP//qRT-PCR//Luciferase Report Assay//H&E Staining//ELISA
Weak Evidence:

 

Reference

[1] PubMed ID:34895044
Disease Name:Colitis, Ulcerative
Sample:UC cell
Dysfunction Pattern:Interaction(miR-20b-5p/CREB1 )
Validated Method:Western Blot//Tunel//CCK8//Flow Cytometry//FISH//RIP//qRT-PCR//Luciferase Report Assay//H&E Staining//ELISA//Bioinformatics Analysis
Description: Collectively, our findings revealed that M2-EVs carrying MEG3 enhanced UC cell viability and reduced inflammatory responses via the miR-20b-5p/CREB1 axis, thus alleviating UC inflammation.
Causality:Yes
Causal Description:UC mice presented with shortened colon length, lightened weight, increased DAI score, enhanced apoptosis, and significant inflammatory cell infiltration, while M2-EVs reversed these trends. In vitro, M2-EVs increased UC cell viability and reduced inflammation.
Clinical-realted Application: