Entry Detail

General Information

Database ID: LDA0007941
Species: Homo sapiens
Confidence Score: 0.985791
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:MIAT
Full Name:myocardial infarction associated transcript
Category:LncRNA
Species:Homo sapiens
Synonyms:C22orf35|GOMAFU|LINC00066|NCRNA00066|RNCR2|lncRNA-MIAT
Chromosome:22
Strand:+
Coordinate:
Start Site(bp):26657482End Site(bp):26676478
External Links:
Ensembl ID:ENSG00000225783
Ensembl Transcript ID:N/A
Entrez Gene:440823.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:66   
More Information
Causal Disease Number:52
Network:
Top Causal Diseases:
Breast Neoplasms  (Score: 0.999998)
Breast Neoplasms  (Score: 0.999998)
Stomach Neoplasms  (Score: 0.999893)
Carcinoma, Hepatocellular  (Score: 0.999893)
Carcinoma, Hepatocellular  (Score: 0.999893)
Stomach Neoplasms  (Score: 0.999893)
Thyroid Cancer, Papillary  (Score: 0.985791)
Diabetic Nephropathies  (Score: 0.985791)
acute myocardial infarction  (Score: 0.985791)
Uterine Cervical Neoplasms  (Score: 0.985791)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:9408
Disease Name:acute myocardial infarction
Category:Disease Ontology
Type:Cardiovascular Diseases
Define:
Alias:

 

Disease Association Statistics

Total Associated ncRNA Number:70   
More Information
Causal ncRNA Number:22
Network:
Top Causal ncRNAs:
MIAT  (Score: 0.985791)
Malat1  (Score: 0.985791)
MIAT  (Score: 0.985791)
TTTY15  (Score: 0.985791)
TTTY15  (Score: 0.985791)
Malat1  (Score: 0.985791)
NEAT1  (Score: 0.731059)
CDKN2B-AS1  (Score: 0.731059)
LINC00152  (Score: 0.731059)
lnc-Chaer  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:qRT-PCR
Weak Evidence:

 

Reference

[1] PubMed ID:31661125
Disease Name:acute myocardial infarction
Sample:blood
Dysfunction Pattern:Expression[highly expressed]
Validated Method:qRT-PCR
Description:The results showed that the plasma levels of MIAT were significantly increased in patients with AMI compared with non‑AMI patients.
Causality:Yes
Causal Description:Knockdown of MIAT significantly inhibited cardiomyocyte apoptosis.
Clinical-realted Application:

[2] PubMed ID:31302423
Disease Name:acute myocardial infarction
Sample:blood
Dysfunction Pattern:Expression[highly expressed]
Validated Method:qRT-PCR
Description:Out of the 10 lncRNAs tested, the mRNA level of lncRNA H19, MIAT and MALAT1 were significantly higher in AMI patients than in healthy control (2.3 ± 0.2 vs. 1.0 ± 0.1, p < 0.001, 1.5±0.1 vs. 1.0±0.1, p = 0.002, 1.8±0.2 vs. 1.0±0.1, p < 0.001, respectively).
Causality:No
Causal Description:
Clinical-realted Application: