Entry Detail

General Information

Database ID: LDA0015363
Species: Homo sapiens
Confidence Score: 0.999978
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Unknown
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:MALAT1
Full Name:metastasis associated lung adenocarcinoma transcript 1
Category:LncRNA
Species:Homo sapiens
Synonyms:HCN|LINC00047|NCRNA00047|NEAT2|PRO2853
Chromosome:11
Strand:+
Coordinate:
Start Site(bp):65497738End Site(bp):65506516
External Links:
Ensembl ID:ENSG00000251562
Ensembl Transcript ID:N/A
Entrez Gene:378938.0
NONCODE ID:N/A
RefSeq Accession:NR_002819.4

 

ncRNA Association Statistics

Total Associated Disease Number:204   
More Information
Causal Disease Number:132
Network:
Top Causal Diseases:
Breast Neoplasms  (Score: 1)
Breast Neoplasms  (Score: 1)
Coronary Artery Disease  (Score: 1)
Stomach Neoplasms  (Score: 1)
Colorectal Neoplasms  (Score: 1)
tongue squamous cell carcinoma  (Score: 1)
Colorectal Neoplasms  (Score: 1)
Stomach Neoplasms  (Score: 1)
Carcinoma, Non-Small-Cell Lung  (Score: 1)
Carcinoma, Renal Cell  (Score: 1)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:0080600D000086382
Disease Name:COVID-19COVID-19
Category:Disease OntologyMeSH
Type:Infections
Define:A Coronavirus infection that is characterized by fever, cough and shortness of breath and that has_material_basis_in SARS-CoV-2.A viral disorder generally characterized by high FEVER; COUGH; DYSPNEA; CHILLS; PERSISTENT TREMOR; MUSCLE PAIN; HEADACHE; SORE THROAT; a new loss of taste and/or smell (see AGEUSIA and ANOSMIA) and other symptoms of a VIRAL PNEUMONIA. In severe cases, a myriad of coagulopathy associated symptoms often correlating with COVID-19 severity is seen (e.g., BLOOD COAGULATION; THROMBOSIS; ACUTE RESPIRATORY DISTRESS SYNDROME; SEIZURES; HEART ATTACK; STROKE; multiple CEREBRAL INFARCTIONS; KIDNEY FAILURE; catastrophic ANTIPHOSPHOLIPID ANTIBODY SYNDROME and/or DISSEMINATED INTRAVASCULAR COAGULATION). In younger patients, rare inflammatory syndromes are sometimes associated with COVID-19 (e.g., atypical KAWASAKI SYNDROME; TOXIC SHOCK SYNDROME; pediatric multisystem inflammatory disease; and CYTOKINE STORM SYNDROME). A coronavirus, SARS-CoV-2, in the genus BETACORONAVIRUS is the causative agent.
Alias:2019 Novel Coronavirus (2019-nCoV)//2019-nCoV infection//Wuhan coronavirus infection//Wuhan seafood market pneumonia virus infectionCOVID-19//COVID 19//2019-nCoV Infection//2019 nCoV Infection//2019-nCoV Infections//Infection, 2019-nCoV//SARS-CoV-2 Infection//Infection, SARS-CoV-2//SARS CoV 2 Infection//SARS-CoV-2 Infections//2019 Novel Coronavirus Disease//2019 Novel Coronavirus Infection//COVID-19 Virus Infection//COVID 19 Virus Infection//COVID-19 Virus Infections//Infection, COVID-19 Virus//Virus Infection, COVID-19//COVID19//Coronavirus Disease 2019//Disease 2019, Coronavirus//Coronavirus Disease-19//Coronavirus Disease 19//Severe Acute Respiratory Syndrome Coronavirus 2 Infection//COVID-19 Virus Disease//COVID 19 Virus Disease//COVID-19 Virus Diseases//Disease, COVID-19 Virus//Virus Disease, COVID-19//SARS Coronavirus 2 Infection//2019-nCoV Disease//2019 nCoV Disease//2019-nCoV Diseases//Disease, 2019-nCoV//COVID-19 Pandemic//COVID 19 Pandemic//Pandemic, COVID-19//COVID-19 Pandemics

 

Disease Association Statistics

Total Associated ncRNA Number:116   
More Information
Causal ncRNA Number:0
Network:
Top Causal ncRNAs:
More Information

 

Evidence Support

Strong Evidence:qRT-PCR
Weak Evidence:RNA-seq//Bioinformatics Analysis

 

Reference

[1] PubMed ID:33520952
Disease Name:COVID-19
Sample:COVID-19 patients
Dysfunction Pattern:Regulation
Validated Method:Bioinformatics Analysis
Description:This project aims to computationally identify conserved lncRNAs potentially regulating gene expression in cytokine storm during COVID-19. We found 22 lncRNAs that can target 10 cytokines overexpressed in COVID-19 cytokine storm, 8 of which targeted two or more cytokine storm cytokines. In particular, the lncRNA non-coding RNA activated by DNA damage (NORAD), targeted five out of the ten identified cytokine storm cytokines, and is evolutionarily conserved across multiple species. These lncRNAs are ideal candidates for further in vitro and in vivo analysis.
Causality:No
Causal Description:
Clinical-realted Application:

[2] PubMed ID:34463043
Disease Name:COVID-19
Sample:saliva and nasopharyngeal swab samples
Dysfunction Pattern:Expression(highly expressed)
Validated Method:qRT-PCR
Description:We evaluated the expression of lncRNAs NEAT1, MALAT1, and MIR3142 in saliva and nasopharyngeal swab from SARS-CoV-2 positive (n = 34) and negative patients (n = 46). A higher expression of the lncRNAs NEAT1 and MALAT1 (p < 0.05) were found in positive samples. NEAT1 had a higher expression mainly in saliva samples (p < 0.001), and MALAT1 was upregulated in nasopharyngeal samples (p < 0.05). Area under the ROC curve for NEAT1 in saliva was 0.8067. This study was the first to investigate the expression of lncRNAs in saliva and nasopharyngeal samples of COVID-19 patients, which gives new insights into the initial response to infection and infectivity and may provide new biomarkers for severity and targets for therapy.
Causality:No
Causal Description:
Clinical-realted Application:

[3] PubMed ID:35007307
Disease Name:COVID-19
Sample:peripheral blood mononuclear cells
Dysfunction Pattern:Expression(highly expressed)
Validated Method:RNA-seq
Description:The immunomodulatory long non-coding RNAs (lncRNAs) NEAT1 and MALAT1 were highly differentially expressed between mild and severe patients in multiple cell types.
Causality:No
Causal Description:
Clinical-realted Application:

[4] PubMed ID:35500644
Disease Name:COVID-19
Sample:Peripheral Blood Mononuclear Cell
Dysfunction Pattern:Expression(highly expressed)
Validated Method:qRT-PCR
Description:The mean expression levels of MALAT-1, THRIL, and miR-155-5p were significantly increased in the acute phase of COVID-19 compared with a healthy control group. In addition, the expression levels of MALAT-1 and THRIL in the post-acute phase of COVID-19 were significantly lower than in the acute phase of COVID-19. According to the ROC curve analysis, these ncRNAs could be considered useful biomarkers for COVID-19 diagnosis and for discriminating between acute and post-acute phase of COVID-19.
Causality:No
Causal Description:
Clinical-realted Application: