| [1] PubMed ID: | 31024342 |
| Disease Name: | Abortion, Habitual |
| Sample: | blood |
| Dysfunction Pattern: | Mutation[rs619586 ] |
| Validated Method: | Genotyping |
| Description: | Our results showed that the rs619586 G variant had protective effects against recurrent miscarriage (AG vs. AA: adjusted OR = 0.670, 95% CI = 0.457-0.982, p = 0.040; GG vs. AA: adjusted OR = 0.278, 95% CI = 0.079-0.975, p = 0.046; GG/AG vs. AA adjusted OR = 0.621, 95% CI = 0.429-0.900, p = 0.012). In a combined analyses of protective genotypes, with regard to the three single nucleotide polymorphisms (SNPs), we found that individuals with two or three protective genotypes exhibited a significantly lower risk of recurrent miscarriage than those with no or only one protective genotype (adjusted OR = 0.369, 95% CI = 0.199-0.684, p = 0.002). Moreover, the decrease in recurrent miscarriage risk with two or three protective genotypes was most pronounced in women less than 35 years of age (OR = 0.290, 95% CI = 0.142-0.589, p < 0.001) and in women with 2-3 miscarriages (adjusted OR = 0.270, 95% CI = 0.126-0.580, p < 0.001). In conclusion, our study suggests that the rs619586 G variant may have potential protective effects conferring a decreased risk of recurrent miscarriage in the southern Chinese population. |
| Causality: | No |
| Causal Description: | |
| Clinical-realted Application: | |
| [2] PubMed ID: | 30848022 |
| Disease Name: | Abortion, Habitual |
| Sample: | blood |
| Dysfunction Pattern: | Regulation[p53-MALAT1 pathway] |
| Validated Method: | qRT-PCR//Luciferase Report Assay |
| Description: | We found the level of NEAT1 and MALAT1 was reduced significantly and only the MALAT1 level negatively correlated with p53 protein level. |
| Causality: | No |
| Causal Description: | |
| Clinical-realted Application: | |
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