Entry Detail

General Information

Database ID: LDA0015383
Species: Homo sapiens
Confidence Score: 0.985791
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Unknown
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:MALAT1
Full Name:metastasis associated lung adenocarcinoma transcript 1
Category:LncRNA
Species:Homo sapiens
Synonyms:HCN|LINC00047|NCRNA00047|NEAT2|PRO2853
Chromosome:11
Strand:+
Coordinate:
Start Site(bp):65497738End Site(bp):65506516
External Links:
Ensembl ID:ENSG00000251562
Ensembl Transcript ID:N/A
Entrez Gene:378938.0
NONCODE ID:N/A
RefSeq Accession:NR_002819.4

 

ncRNA Association Statistics

Total Associated Disease Number:204   
More Information
Causal Disease Number:132
Network:
Top Causal Diseases:
Breast Neoplasms  (Score: 1)
Breast Neoplasms  (Score: 1)
Coronary Artery Disease  (Score: 1)
Stomach Neoplasms  (Score: 1)
Colorectal Neoplasms  (Score: 1)
tongue squamous cell carcinoma  (Score: 1)
Colorectal Neoplasms  (Score: 1)
Stomach Neoplasms  (Score: 1)
Carcinoma, Non-Small-Cell Lung  (Score: 1)
Carcinoma, Renal Cell  (Score: 1)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:7148D001172
Disease Name:rheumatoid arthritisArthritis, Rheumatoid
Category:Disease OntologyMeSH
Type:Musculoskeletal Diseases
Define:An arthritis that is an autoimmune disease which attacks healthy cells and tissue located_in joint.A chronic systemic disease, primarily of the joints, marked by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. Etiology is unknown, but autoimmune mechanisms have been implicated.
Alias:Arthritis or polyarthritis, rheumatic//atrophic ArthritisArthritis, Rheumatoid//Rheumatoid Arthritis

 

Disease Association Statistics

Total Associated ncRNA Number:134   
More Information
Causal ncRNA Number:64
Network:
Top Causal ncRNAs:
GAS5  (Score: 1)
GAS5  (Score: 1)
NEAT1  (Score: 1)
NEAT1  (Score: 1)
LINC00638  (Score: 0.999893)
THRIL  (Score: 0.999893)
THRIL  (Score: 0.999893)
LINC00638  (Score: 0.999893)
ZFAS1  (Score: 0.985791)
MEG3  (Score: 0.985791)
More Information

 

Evidence Support

Strong Evidence:qRT-PCR
Weak Evidence:

 

Reference

[1] PubMed ID:33026292
Disease Name:Arthritis, Rheumatoid
Sample:blood
Dysfunction Pattern:Expression[highly expressed]
Validated Method:qRT-PCR
Description:MALAT1, MEG3, NEAT1 were increased in PBMCs, plasma, synovial fluid (p < 0.05) of RA patients.
Causality:No
Causal Description:
Clinical-realted Application:

[2] PubMed ID:32133566
Disease Name:Arthritis, Rheumatoid
Sample:peripheral blood mononuclear cells
Dysfunction Pattern:Expression[highly expressed]
Validated Method:qRT-PCR
Description:The expression levels of NR_002819, NR_038935, and ENST00000603415 were significantly increased in the RA-ILD group, while the expression level of ENST00000560199 was significantly decreased.
Causality:No
Causal Description:
Clinical-realted Application: