Entry Detail

General Information

Database ID: LDA0015389
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Unknown
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:MALAT1
Full Name:metastasis associated lung adenocarcinoma transcript 1
Category:LncRNA
Species:Homo sapiens
Synonyms:HCN|LINC00047|NCRNA00047|NEAT2|PRO2853
Chromosome:11
Strand:+
Coordinate:
Start Site(bp):65497738End Site(bp):65506516
External Links:
Ensembl ID:ENSG00000251562
Ensembl Transcript ID:N/A
Entrez Gene:378938.0
NONCODE ID:N/A
RefSeq Accession:NR_002819.4

 

ncRNA Association Statistics

Total Associated Disease Number:204   
More Information
Causal Disease Number:132
Network:
Top Causal Diseases:
Breast Neoplasms  (Score: 1)
Breast Neoplasms  (Score: 1)
Coronary Artery Disease  (Score: 1)
Stomach Neoplasms  (Score: 1)
Colorectal Neoplasms  (Score: 1)
tongue squamous cell carcinoma  (Score: 1)
Colorectal Neoplasms  (Score: 1)
Stomach Neoplasms  (Score: 1)
Carcinoma, Non-Small-Cell Lung  (Score: 1)
Carcinoma, Renal Cell  (Score: 1)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:8893D011565
Disease Name:psoriasisPsoriasis
Category:Disease OntologyMeSH
Type:Skin and Connective Tissue Diseases
Define:A skin disease that is characterized by patches of thick red skin and silvery scales.A common genetically determined, chronic, inflammatory skin disease characterized by rounded erythematous, dry, scaling patches. The lesions have a predilection for nails, scalp, genitalia, extensor surfaces, and the lumbosacral region. Accelerated epidermopoiesis is considered to be the fundamental pathologic feature in psoriasis.
Alias:Psoriasis//Psoriases//Pustulosis of Palms and Soles//Pustulosis Palmaris et Plantaris//Palmoplantaris Pustulosis//Pustular Psoriasis of Palms and Soles

 

Disease Association Statistics

Total Associated ncRNA Number:28   
More Information
Causal ncRNA Number:18
Network:
Top Causal ncRNAs:
HOTAIR  (Score: 0.731059)
NORAD  (Score: 0.731059)
Meg3  (Score: 0.731059)
SPRR2C  (Score: 0.731059)
circVAPA  (Score: 0.731059)
circEIF5  (Score: 0.731059)
XIST  (Score: 0.731059)
AGAP2-AS1  (Score: 0.731059)
chr2:206992521|206994966  (Score: 0.731059)
HOTAIR  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:Genotyping
Weak Evidence:

 

Reference

[1] PubMed ID:34846099
Disease Name:Psoriasis
Sample:Iranian patients
Dysfunction Pattern:Mutation(rs619586, rs3200401)
Validated Method:Genotyping
Description:We investigated the associations between two genetic variants in MALAT1 and susceptibility to psoriasis in the Iranian population. The G allele of rs619586 has been shown to be less common among cases versus controls (odds ratios (OR; 95% confidence intervals (CI)) = 0.57 (0.36-0.9)), adjusted p = .02). This single nucleotide polymorphism has been associated with the risk of psoriasis in a dominant model (AG + GG vs. AA: OR (95% CI) = 0.56 (0.35-0.92), adjusted p = .04) as well as log-additive model (OR (95% CI) = 0.59 (0.38-0.92), adjusted p = .04). The rs3200401 was not associated with psoriasis in any of the supposed inheritance models. This study potentiates rs619586 as a risk locus for psoriasis in the Iranian population
Causality:No
Causal Description:
Clinical-realted Application: