Entry Detail

General Information

Database ID: LDA0015395
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Unknown
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:MALAT1
Full Name:metastasis associated lung adenocarcinoma transcript 1
Category:LncRNA
Species:Homo sapiens
Synonyms:HCN|LINC00047|NCRNA00047|NEAT2|PRO2853
Chromosome:11
Strand:+
Coordinate:
Start Site(bp):65497738End Site(bp):65506516
External Links:
Ensembl ID:ENSG00000251562
Ensembl Transcript ID:N/A
Entrez Gene:378938.0
NONCODE ID:N/A
RefSeq Accession:NR_002819.4

 

ncRNA Association Statistics

Total Associated Disease Number:204   
More Information
Causal Disease Number:132
Network:
Top Causal Diseases:
Breast Neoplasms  (Score: 1)
Breast Neoplasms  (Score: 1)
Coronary Artery Disease  (Score: 1)
Stomach Neoplasms  (Score: 1)
Colorectal Neoplasms  (Score: 1)
tongue squamous cell carcinoma  (Score: 1)
Colorectal Neoplasms  (Score: 1)
Stomach Neoplasms  (Score: 1)
Carcinoma, Non-Small-Cell Lung  (Score: 1)
Carcinoma, Renal Cell  (Score: 1)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:D054058
Disease Name:Acute Coronary Syndrome
Category:MeSH
Type:Cardiovascular Diseases
Define:An episode of MYOCARDIAL ISCHEMIA that generally lasts longer than a transient anginal episode that ultimately may lead to MYOCARDIAL INFARCTION.
Alias:Acute Coronary Syndrome//Acute Coronary Syndromes//Coronary Syndrome, Acute//Coronary Syndromes, Acute//Syndrome, Acute Coronary//Syndromes, Acute Coronary

 

Disease Association Statistics

Total Associated ncRNA Number:88   
More Information
Causal ncRNA Number:2
Network:
Top Causal ncRNAs:
ENST00000538705.1  (Score: 0.731059)
ENST00000538705.1  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:Genotyping
Weak Evidence:

 

Reference

[1] PubMed ID:33968621
Disease Name:Acute Coronary Syndrome
Sample:92 ACS patients and 92 controls
Dysfunction Pattern:Mutation(rs600231 )
Validated Method:Genotyping
Description:The prevalence of the GG genotype of rs600231 in ACS group was higher than that in control group (15.7% vs. 14.7%, P=0.048). The dominant model differed (AG + GG vs. AA) and the G allele of rs600231 in ACS group was higher than that in control group (for dominant model: 66.2% vs. 60.9%, P=0.014; for allele: 41.0% vs. 37.8%, P=0.042). In addition, in the AG and GG phenotypes, the relative expression of lncRNA MALAT1 was significantly higher in ACS patients than in controls with the same phenotypes (P<0.05).
Causality:No
Causal Description:
Clinical-realted Application: